{"title":"GHRH \/ GHRP Peptides","description":"","products":[{"product_id":"igf-1-lr3-1mg","title":"IGF-1 LR3 .1mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nIGF-1 LR3 (Insulin-Like Growth Factor-1 Long R3) is a synthetic modified form of IGF-1, designed to extend its biological activity by preventing binding to IGF-binding proteins. This modification makes IGF-1 LR3 up to 120 times longer-lasting than standard IGF-1, significantly enhancing its effects on cell growth, metabolism, and muscle repair.\u003cbr\u003e\nResearch suggests IGF-1 LR3 may:\u003c\/p\u003e\n\n\u003cp\u003eStimulate cell division and tissue growth, affecting muscles, bones, nerves, and vital organs.\u003cbr\u003e\nEnhance fat metabolism, leading to reduced adipose tissue and improved glucose regulation.\u003cbr\u003e\nSupport muscle repair and hypertrophy, by counteracting myostatin’s inhibitory effects.\u003cbr\u003e\nPromote longevity and cellular maintenance, by reducing age-related tissue degeneration.\u003cbr\u003e\nProtect against glucocorticoid-induced muscle loss, supporting muscle preservation in individuals undergoing corticosteroid therapy.\u003c\/p\u003e\n\n\u003cp\u003eDue to these properties, IGF-1 LR3 has been explored in muscle-wasting conditions, diabetes research, and anti-aging therapies.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nIGF-1 LR3 and Cell Growth\u003c\/p\u003e\n\n\u003cp\u003eIGF-1 LR3 is a potent stimulator of cell division and proliferation.\u003cbr\u003e\nPrimarily affects muscles and bones, but also influences liver, kidney, nerve, skin, lung, and blood tissues.\u003cbr\u003e\nLonger circulation time compared to IGF-1, making it more effective in promoting cell maturation and tissue regeneration.\u003cbr\u003e\nPotential application: Regenerative medicine and muscle recovery.\u003c\/p\u003e\n\n\u003cp\u003eIGF-1 LR3 and Fat Metabolism\u003c\/p\u003e\n\n\u003cp\u003eIGF-1 LR3 binds to insulin receptors, enhancing glucose uptake in muscle, liver, and nerve cells.\u003cbr\u003e\nThis leads to lower blood sugar levels, triggering fat breakdown and a net decrease in adipose tissue.\u003cbr\u003e\nPotential application: Obesity management and diabetes therapy.\u003c\/p\u003e\n\n\u003cp\u003eIGF-1 LR3 and Muscle Growth (Myostatin Inhibition)\u003c\/p\u003e\n\n\u003cp\u003eMyostatin is a natural inhibitor of muscle growth—IGF-1 LR3 blocks its effects, allowing enhanced muscle repair and hypertrophy.\u003cbr\u003e\nResearch suggests IGF-1 LR3 may be beneficial for conditions such as Duchenne Muscular Dystrophy (DMD) and muscle atrophy due to immobility or chronic illness.\u003cbr\u003e\nPotential application: Muscle-wasting disorder treatment and sports performance research.\u003c\/p\u003e\n\n\u003cp\u003eIGF-1 LR3 and Longevity Research\u003c\/p\u003e\n\n\u003cp\u003eIGF-1 LR3 supports tissue repair and maintenance, offering protective benefits against age-related decline.\u003cbr\u003e\nStudies in livestock models (cows and pigs) suggest IGF-1 LR3 can counteract cellular aging effects.\u003cbr\u003e\nOngoing research in mice explores IGF-1 LR3’s role in preventing dementia, muscle loss, and kidney disease.\u003cbr\u003e\nPotential application: Anti-aging and age-related disease prevention.\u003c\/p\u003e\n\n\u003cp\u003eIGF-1 LR3 and Glucocorticoid Protection\u003c\/p\u003e\n\n\u003cp\u003eGlucocorticoids are commonly used anti-inflammatory drugs, but long-term use can cause muscle wasting, fat gain, and bone density loss.\u003cbr\u003e\nIGF-1 LR3 counteracts these negative effects, allowing for more effective corticosteroid therapy with reduced side effects.\u003cbr\u003e\nPotential application: Muscle preservation in patients undergoing glucocorticoid therapy.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₄₀₀H₆₂₅N₁₁₁O₁₁₅S₉\u003cbr\u003e\nMolecular Weight: 9117.5 g\/mol\u003cbr\u003e\nAmino Acid Sequence:\u003cbr\u003e\nMFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSA\u003cbr\u003e\nCAS Registry Number: 946870-92-4\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eAdipose Tissue-Derived Stem Cell Secreted IGF-1 Protects Myoblasts from the Negative Effect of Myostatin. Hindawi Journal.\u003cbr\u003e\nN. Li, Q. Yang, R. G. Walker, T. B. Thompson, M. Du, and B. D. Rodgers. Myostatin Attenuation In Vivo Reduces Adiposity, but Activates Adipogenesis. Endocrinology (2016).\u003cbr\u003e\nE. Corpas, S. M. Harman, and M. R. Blackman. Human growth hormone and human aging. Endocr. Rev. (1993).\u003cbr\u003e\nW. E. Sonntag, A. Csiszar, R. deCabo, L. Ferrucci, and Z. Ungvari. Diverse roles of growth hormone and insulin-like growth factor-1 in mammalian aging: progress and controversies. J. Gerontol. A. Biol. Sci. Med. Sci. (2012).\u003cbr\u003e\nIGF-I\/IGFBP system: metabolism outline and physical exercise. NCBI.\u003cbr\u003e\nB. Y. Hanaoka, C. A. Peterson, C. Horbinski, and L. J. Crofford. Implications of glucocorticoid therapy in idiopathic inflammatory myopathies. Nat. Rev. Rheumatol. (2012).\u003cbr\u003e\nA. Philippou, A. Halapas, M. Maridaki, M. Koutsilieris. Expression of IGF-1 isoforms after exercise-induced muscle damage in humans. J. Musculoskelet Neuronal Interact. (2007).\u003cbr\u003e\nA. Philippou, E. Papageorgiou, G. Bogdanis, A. Halapas. Characterization of the MGF E peptide actions in vitro. In Vivo (2009).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560037609,"sku":"PS049-1","price":80.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/IGF-1-LR3-1mg-1.jpg?v=1778509456"},{"product_id":"sermorelin-5mg","title":"Sermorelin 5mg","description":"OVERVIEW\nSermorelin is a synthetic analogue of growth hormone-releasing hormone (GHRH), designed to stimulate natural growth hormone (GH) secretion. It has been widely researched for its clinical applications in GH assessment and its potential benefits in cardiovascular health, cognitive function, and metabolic regulation.\nStudies suggest Sermorelin may:\n\nIncrease bone density, supporting skeletal health.\nReduce scarring, aiding in tissue healing and wound repair.\nEnhance renal function, potentially benefiting kidney health.\nSupport cognitive function and fight dementia, by promoting neuronal protection.\nReduce seizure activity, through GABA receptor interactions.\nImprove cardiovascular health, by aiding heart tissue repair after damage.\n\nUnlike direct GH therapy, Sermorelin preserves the body’s natural GH regulation, reducing the risk of overdosing, joint pain, and GH desensitization.\nRESEARCH\nSermorelin and Heart Health\n\nResearch in pig models demonstrated that Sermorelin reduces cardiac remodeling following a heart attack.\nMechanisms include:\n\nDecreasing cardiomyocyte (heart cell) death.\nEnhancing extracellular matrix production, supporting tissue healing.\nStimulating new blood vessel growth, improving circulation.\nReducing inflammation, lowering further heart damage risk.\n\n\nPotential application: Post-myocardial infarction recovery and heart failure management.\n\nSermorelin and Epilepsy\n\nStudies suggest Sermorelin activates GABA receptors, which help suppress seizures.\nAnimal models of epilepsy showed that GHRH analogues reduce seizure activity.\nPotential application: Adjunctive therapy for seizure disorders.\n\nSermorelin and Sleep Regulation\n\nSermorelin may influence orexin, a key neurochemical regulating wakefulness and sleep cycles.\nExogenous administration of Sermorelin has been linked to more stable sleep patterns.\nPotential application: Treatment for sleep disturbances and optimization of sleep quality.\n\nSermorelin as a Preferred Alternative to GH Therapy\nUnlike direct GH administration, Sermorelin:\n\nPreserves physiological GH feedback mechanisms, reducing the risk of GH overdose and dysregulation.\nDoes not cause tachyphylaxis (desensitization), meaning the body does not lose sensitivity to its effects over time.\nHas a lower risk of side effects, such as edema, joint pain, and metabolic imbalances.\nPotential application: Safer alternative for individuals requiring GH optimization.\n\nSTRUCTURE\n\nMolecular Formula: C₁₄₉H₂₄₆N₄₄O₄₂S\nMolecular Weight: 3357.933 g\/mol\nAmino Acid Sequence:\nTyr-DL-Ala-DL-Asp-DL-Ala-DL-xiIle-DL-Phe-DL-xiThr-DL-Asn-DL-Ser-DL-Tyr-DL-Arg-DL-Lys-DL-Val-DL-Leu-Gly-DL-Gln-DL-Leu-DL-Ser-DL-Ala-DL-Arg-DL-Lys-DL-Leu-DL-Leu-DL-Gln-DL-Asp-DL-xiIle-DL-Met-DL-Ser-DL-Arg\nCAS Registry Number: 86168-78-7\n\nCITATIONS\n\nL. L. Bagno et al. Growth Hormone–Releasing Hormone Agonists Reduce Myocardial Infarct Scar in Swine With Subacute Ischemic Cardiomyopathy. J. Am. Heart Assoc. Cardiovasc. Cerebrovasc. Dis. (2015).\nR. M. Kanashiro-Takeuchi et al. New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget (2015).\nS. Tang et al. Interactions between GHRH and GABAARs in the brains of patients with epilepsy and in animal models of epilepsy. Sci. Rep. (2017).\nB. S. Shepherd et al. Endocrine and orexigenic actions of growth hormone secretagogues in rainbow trout (Oncorhynchus mykiss). Comp. Biochem. Physiol. A. Mol. Integr. Physiol. (2007).\nR. F. Walker. Sermorelin: A better approach to management of adult-onset growth hormone insufficiency? Clin. Interv. Aging (2006).\nS. T. Wahid et al. Partial tachyphylaxis to somatostatin (SST) analogues in a patient with acromegaly: the role of SST receptor desensitisation and circulating antibodies to SST analogues. Eur. J. Endocrinol. (2002).","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560791273,"sku":"PS045","price":50.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Sermorelin-5mg-scaled.jpg?v=1778509477"},{"product_id":"ipamorelin-10mg","title":"Ipamorelin 10mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nIpamorelin is a highly selective growth hormone secretagogue (GHS) that binds specifically to the ghrelin\/growth hormone secretagogue receptor (GHS-R1a). It is one of the most targeted GH secretagogues, meaning it does notaffect levels of ACTH, prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or cortisol.\u003cbr\u003e\nDue to its high receptor specificity, Ipamorelin has been widely studied for therapeutic applications and as a model peptide for exploring GH receptor selectivity. It plays a key role in growth, tissue repair, and metabolic regulation.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nIpamorelin and Growth Hormone Release\u003cbr\u003e\nIpamorelin mimics ghrelin, the body’s natural hunger hormone, by binding to GHS-R1a receptors. This interaction leads to:\u003c\/p\u003e\n\n\u003cp\u003eA natural increase in growth hormone (GH) levels.\u003cbr\u003e\nImproved muscle growth, fat metabolism, and tissue repair.\u003cbr\u003e\nPreserved GH pulse frequency without overstimulating the endocrine system.\u003c\/p\u003e\n\n\u003cp\u003eUnlike other GH secretagogues, Ipamorelin stimulates GH release without causing significant increases in cortisol or prolactin levels, making it a safer option for long-term use.\u003cbr\u003e\nIpamorelin and Corticosteroid Side Effects\u003cbr\u003e\nGlucocorticoids (steroids) are often used to treat inflammatory diseases and cancer, but long-term use can lead to:\u003c\/p\u003e\n\n\u003cp\u003eMuscle wasting\u003cbr\u003e\nLoss of bone density\u003cbr\u003e\nIncreased visceral fat accumulation\u003c\/p\u003e\n\n\u003cp\u003eStudies suggest that Ipamorelin may counteract these side effects by:\u003c\/p\u003e\n\n\u003cp\u003eReducing muscle breakdown.\u003cbr\u003e\nPreventing bone loss associated with prolonged steroid use.\u003cbr\u003e\nPreserving nitrogen balance, which is crucial for muscle maintenance and recovery.\u003c\/p\u003e\n\n\u003cp\u003eIpamorelin and Bone Health\u003cbr\u003e\nChronic steroid use is linked to osteoporosis and increased fracture risk. Research in animal models has demonstrated that Ipamorelin can:\u003c\/p\u003e\n\n\u003cp\u003ePrevent bone density loss.\u003cbr\u003e\nStimulate osteoblast activity, promoting new bone formation.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest Ipamorelin may have therapeutic applications in conditions like osteoporosis and age-related bone deterioration.\u003cbr\u003e\nIpamorelin and Muscle Growth\u003cbr\u003e\nIpamorelin’s ability to enhance protein synthesis makes it beneficial for:\u003c\/p\u003e\n\n\u003cp\u003eIncreasing muscle mass and improving recovery.\u003cbr\u003e\nPreventing muscle wasting conditions, such as cachexia and sarcopenia.\u003cbr\u003e\nSupporting post-surgical healing and injury rehabilitation.\u003c\/p\u003e\n\n\u003cp\u003eBy promoting muscle hypertrophy and repair, Ipamorelin has gained interest in sports medicine and anti-aging research.\u003cbr\u003e\nIpamorelin and Diabetes Research\u003cbr\u003e\nStudies suggest that Ipamorelin can stimulate insulin release by activating calcium channels in pancreatic islet cells. This mechanism may:\u003c\/p\u003e\n\n\u003cp\u003eImprove insulin sensitivity.\u003cbr\u003e\nAid in blood sugar regulation.\u003c\/p\u003e\n\n\u003cp\u003eThese findings indicate that Ipamorelin may be explored as a potential treatment for diabetes.\u003cbr\u003e\nIpamorelin and Post-Operative Ileus (POI)\u003cbr\u003e\nPost-operative ileus (POI) occurs when the digestive tract temporarily stops functioning after surgery, delaying recovery.\u003cbr\u003e\nClinical trials have shown that Ipamorelin:\u003c\/p\u003e\n\n\u003cp\u003eReduces POI symptoms.\u003cbr\u003e\nShortens hospital stays by an average of 12 hours.\u003c\/p\u003e\n\n\u003cp\u003eAlthough initial results were promising, further research on Ipamorelin for POI treatment was discontinued due to insufficient efficacy in large-scale trials.\u003cbr\u003e\nIpamorelin and PET Imaging\u003cbr\u003e\nAs a potent ghrelin receptor agonist, Ipamorelin has potential applications in diagnostic imaging:\u003c\/p\u003e\n\n\u003cp\u003eCould be used in PET scans to detect ghrelin receptor-overexpressing tumors.\u003cbr\u003e\nMay aid in diagnosing conditions related to GH deficiency or metabolic disorders.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₃₈H₄₉N₉O₅\u003cbr\u003e\nMolecular Weight: 711.868 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Aib-His-D-2Nal-D-Phe-Lys\u003cbr\u003e\nCAS Registry Number: 170851-70-4\u003cbr\u003e\nPubChem Identifier: 9831659\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eRaun, K. et al. Ipamorelin, the first selective growth hormone secretagogue. Eur. J. Endocrinol. (1998).\u003cbr\u003e\nAndersen, N. B. et al. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced bone loss. Growth Horm. IGF Res. (2001).\u003cbr\u003e\nSvensson, J. et al. Ipamorelin increases bone mineral content in female rats. J. Endocrinol. (2000).\u003cbr\u003e\nAagaard, N. K. et al. GH secretagogues reduce nitrogen loss in steroid-treated rats. Growth Horm. IGF Res. (2009).\u003cbr\u003e\nAdeghate, E. \u0026amp; Ponery, A. S. Ipamorelin stimulates insulin release in diabetic rats. Neuro Endocrinol. Lett. (2004).\u003cbr\u003e\nBeck, D. E. et al. Ipamorelin for management of post-operative ileus in bowel resection patients. Int. J. Colorectal Dis. (2014).\u003cbr\u003e\nGreenwood-Van Meerveld, B. et al. Ipamorelin improves gastric dysmotility in POI models. J. Exp. Pharmacol. (2012).\u003cbr\u003e\nFowkes, M. M. et al. Peptidomimetic GH secretagogue derivatives for PET imaging. Eur. J. Med. Chem. (2018).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561250025,"sku":"PS028","price":70.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Ipamorelin-10mg-scaled.jpg?v=1778509490"},{"product_id":"ipamorelin-5mg","title":"Ipamorelin 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nIpamorelin is a highly selective growth hormone secretagogue (GHS) that binds specifically to the ghrelin\/growth hormone secretagogue receptor (GHS-R1a). It is one of the most targeted GH secretagogues, meaning it does notaffect levels of ACTH, prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or cortisol.\u003cbr\u003e\nDue to its high receptor specificity, Ipamorelin has been widely studied for therapeutic applications and as a model peptide for exploring GH receptor selectivity. It plays a key role in growth, tissue repair, and metabolic regulation.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nIpamorelin and Growth Hormone Release\u003cbr\u003e\nIpamorelin mimics ghrelin, the body’s natural hunger hormone, by binding to GHS-R1a receptors. This interaction leads to:\u003c\/p\u003e\n\n\u003cp\u003eA natural increase in growth hormone (GH) levels.\u003cbr\u003e\nImproved muscle growth, fat metabolism, and tissue repair.\u003cbr\u003e\nPreserved GH pulse frequency without overstimulating the endocrine system.\u003c\/p\u003e\n\n\u003cp\u003eUnlike other GH secretagogues, Ipamorelin stimulates GH release without causing significant increases in cortisol or prolactin levels, making it a safer option for long-term use.\u003cbr\u003e\nIpamorelin and Corticosteroid Side Effects\u003cbr\u003e\nGlucocorticoids (steroids) are often used to treat inflammatory diseases and cancer, but long-term use can lead to:\u003c\/p\u003e\n\n\u003cp\u003eMuscle wasting\u003cbr\u003e\nLoss of bone density\u003cbr\u003e\nIncreased visceral fat accumulation\u003c\/p\u003e\n\n\u003cp\u003eStudies suggest that Ipamorelin may counteract these side effects by:\u003c\/p\u003e\n\n\u003cp\u003eReducing muscle breakdown.\u003cbr\u003e\nPreventing bone loss associated with prolonged steroid use.\u003cbr\u003e\nPreserving nitrogen balance, which is crucial for muscle maintenance and recovery.\u003c\/p\u003e\n\n\u003cp\u003eIpamorelin and Bone Health\u003cbr\u003e\nChronic steroid use is linked to osteoporosis and increased fracture risk. Research in animal models has demonstrated that Ipamorelin can:\u003c\/p\u003e\n\n\u003cp\u003ePrevent bone density loss.\u003cbr\u003e\nStimulate osteoblast activity, promoting new bone formation.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest Ipamorelin may have therapeutic applications in conditions like osteoporosis and age-related bone deterioration.\u003cbr\u003e\nIpamorelin and Muscle Growth\u003cbr\u003e\nIpamorelin’s ability to enhance protein synthesis makes it beneficial for:\u003c\/p\u003e\n\n\u003cp\u003eIncreasing muscle mass and improving recovery.\u003cbr\u003e\nPreventing muscle wasting conditions, such as cachexia and sarcopenia.\u003cbr\u003e\nSupporting post-surgical healing and injury rehabilitation.\u003c\/p\u003e\n\n\u003cp\u003eBy promoting muscle hypertrophy and repair, Ipamorelin has gained interest in sports medicine and anti-aging research.\u003cbr\u003e\nIpamorelin and Diabetes Research\u003cbr\u003e\nStudies suggest that Ipamorelin can stimulate insulin release by activating calcium channels in pancreatic islet cells. This mechanism may:\u003c\/p\u003e\n\n\u003cp\u003eImprove insulin sensitivity.\u003cbr\u003e\nAid in blood sugar regulation.\u003c\/p\u003e\n\n\u003cp\u003eThese findings indicate that Ipamorelin may be explored as a potential treatment for diabetes.\u003cbr\u003e\nIpamorelin and Post-Operative Ileus (POI)\u003cbr\u003e\nPost-operative ileus (POI) occurs when the digestive tract temporarily stops functioning after surgery, delaying recovery.\u003cbr\u003e\nClinical trials have shown that Ipamorelin:\u003c\/p\u003e\n\n\u003cp\u003eReduces POI symptoms.\u003cbr\u003e\nShortens hospital stays by an average of 12 hours.\u003c\/p\u003e\n\n\u003cp\u003eAlthough initial results were promising, further research on Ipamorelin for POI treatment was discontinued due to insufficient efficacy in large-scale trials.\u003cbr\u003e\nIpamorelin and PET Imaging\u003cbr\u003e\nAs a potent ghrelin receptor agonist, Ipamorelin has potential applications in diagnostic imaging:\u003c\/p\u003e\n\n\u003cp\u003eCould be used in PET scans to detect ghrelin receptor-overexpressing tumors.\u003cbr\u003e\nMay aid in diagnosing conditions related to GH deficiency or metabolic disorders.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₃₈H₄₉N₉O₅\u003cbr\u003e\nMolecular Weight: 711.868 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Aib-His-D-2Nal-D-Phe-Lys\u003cbr\u003e\nCAS Registry Number: 170851-70-4\u003cbr\u003e\nPubChem Identifier: 9831659\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eRaun, K. et al. Ipamorelin, the first selective growth hormone secretagogue. Eur. J. Endocrinol. (1998).\u003cbr\u003e\nAndersen, N. B. et al. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced bone loss. Growth Horm. IGF Res. (2001).\u003cbr\u003e\nSvensson, J. et al. Ipamorelin increases bone mineral content in female rats. J. Endocrinol. (2000).\u003cbr\u003e\nAagaard, N. K. et al. GH secretagogues reduce nitrogen loss in steroid-treated rats. Growth Horm. IGF Res. (2009).\u003cbr\u003e\nAdeghate, E. \u0026amp; Ponery, A. S. Ipamorelin stimulates insulin release in diabetic rats. Neuro Endocrinol. Lett. (2004).\u003cbr\u003e\nBeck, D. E. et al. Ipamorelin for management of post-operative ileus in bowel resection patients. Int. J. Colorectal Dis. (2014).\u003cbr\u003e\nGreenwood-Van Meerveld, B. et al. Ipamorelin improves gastric dysmotility in POI models. J. Exp. Pharmacol. (2012).\u003cbr\u003e\nFowkes, M. M. et al. Peptidomimetic GH secretagogue derivatives for PET imaging. Eur. J. Med. Chem. (2018).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561282793,"sku":"PS027","price":50.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Ipamorelin-5mg-scaled.jpg?v=1778509490"},{"product_id":"cjc-1295-dac-5mg","title":"CJC-1295 DAC 5mg","description":"OVERVIEW\nCJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) designed to increase plasma levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). It is derived from the first 29 amino acids of GHRH, similar to Sermorelin and Modified GRF (1-29), but modified for enhanced stability and efficacy.\nThe DAC (Drug Affinity Complex) version of CJC-1295 includes an additional lysine linker, allowing it to bind to albumin, significantly extending its half-life. This prolonged activity leads to sustained GH release, reducing the need for frequent dosing compared to non-DAC versions.\nKey Benefits of CJC-1295 DAC:\n\nIncreases GH and IGF-1 levels\nEnhances protein synthesis and muscle recovery\nBoosts fat metabolism and supports weight management\nImproves sleep quality and cognitive function\nPreserves natural GH pulsatility, reducing side effects\n\nRESEARCH\nCJC-1295 and Growth Hormone Release\nCJC-1295 binds to GHRH receptors, triggering GH secretion while maintaining the body’s natural pulsatile rhythm. Research findings indicate that:\n\nA single dose of CJC-1295 can increase GH levels by 2-10 times.\nPeak GH secretion occurs around 2 hours post-administration and remains elevated for 6-8 days.\nUnlike exogenous GH injections, which can suppress natural GH production, CJC-1295 stimulates endogenous GH release, minimizing suppression risks.\n\nComparison: CJC-1295 vs. CJC-1295 DAC\n\n\n\nFeature\nCJC-1295 (No DAC)\nCJC-1295 DAC\n\n\nHalf-Life\n~30 minutes\n~8 days\n\n\nDosing Frequency\nMultiple injections daily\nWeekly\n\n\nMechanism\nShort-acting GHRH analogue\nBinds to albumin for sustained GH release\n\n\n\nThe DAC modification allows CJC-1295 to stay in circulation longer, preventing rapid degradation, and promoting longer-lasting GH stimulation.\nEffects on Muscle Growth\nAnimal studies suggest that CJC-1295 enhances lean body mass through:\n\nIncreased protein synthesis, supporting muscle hypertrophy and faster recovery.\nImproved nitrogen retention, aiding in muscle maintenance.\nEnhanced mitochondrial function, potentially boosting endurance and energy production.\n\nCJC-1295 and Fat Metabolism\nCJC-1295 has been linked to fat reduction and improved metabolic function by:\n\nEnhancing GH-induced fatty acid oxidation, leading to more efficient fat breakdown.\nReducing fat accumulation, particularly visceral and subcutaneous fat.\nImproving insulin sensitivity, which helps regulate glucose levels and metabolic efficiency.\n\nClinical studies indicate significant fat loss in subjects using CJC-1295 over 12-24 weeks.\nCJC-1295 and Sleep Quality\nResearch suggests that CJC-1295 may play a role in enhancing sleep cycles, particularly:\n\nIncreasing deep (slow-wave) sleep, crucial for muscle repair, memory consolidation, and recovery.\nModulating cortisol and stress hormones, leading to better relaxation and stress resilience.\n\nThese sleep-related benefits contribute to overall well-being, cognitive function, and physical recovery.\nCJC-1295 and Anti-Aging Potential\nDue to its ability to boost GH and IGF-1 levels, CJC-1295 has been explored for its potential in longevity and regenerative medicine. Benefits may include:\n\nImproved bone density, reducing age-related bone loss.\nEnhanced skin elasticity and collagen production, contributing to youthful skin.\nCognitive protection, potentially aiding in neuroprotection and memory retention.\n\nSTRUCTURE\n\nMolecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂\nMolecular Weight: 3647.954 g\/mol\nAmino Acid Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-DAC\nCAS Registry Number: 446262-90-4\nPubChem Identifier: 91976842\n\nCITATIONS\n\nIonescu, M., \u0026amp; Frohman, L. A. Pulsatile secretion of growth hormone persists during continuous stimulation by CJC-1295. J. Clin. Endocrinol. Metab. (2006).\nAlba, M. et al. Once-daily administration of CJC-1295, a long-acting GHRH analog, normalizes growth in knockout mice. Am. J. Physiol. Endocrinol. Metab. (2006).\nVolpe, A. et al. Clinical use of growth hormone-releasing factor for induction of superovulation. Hum. Reprod. (1991).\nJetté, L. et al. hGRF1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats.Research Gate (2005).","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561315561,"sku":"PS026","price":55.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/CJC-1295-DAC-5MG-scaled.jpg?v=1778509491"},{"product_id":"cjc-1295-without-dac-5mg","title":"CJC-1295 Without DAC 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nCJC-1295 Without DAC is a synthetic growth hormone-releasing hormone (GHRH) analog designed to increase endogenous growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels. Initially developed for medical applications, CJC-1295 has gained attention in research due to its ability to:\u003c\/p\u003e\n\n\u003cp\u003eStimulate GH secretion and prolong its half-life\u003cbr\u003e\nEnhance protein synthesis and muscle growth\u003cbr\u003e\nSupport fat metabolism and improve body composition\u003cbr\u003e\nPromote cellular repair and longevity\u003cbr\u003e\nImprove sleep quality and cognitive function\u003c\/p\u003e\n\n\u003cp\u003eUnlike CJC-1295 with DAC (Drug Affinity Complex), which provides sustained GH release, the version without DAC offers a more natural pulsatile release pattern, closely mimicking physiological GH secretion.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nCJC-1295 and Growth Hormone Secretion\u003cbr\u003e\nCJC-1295 Without DAC functions by binding to the growth hormone-releasing hormone receptor (GHRHR) in the pituitary gland, leading to an increase in GH release. Studies suggest that:\u003c\/p\u003e\n\n\u003cp\u003eGH pulsatility is essential for muscle growth, metabolic regulation, and overall physiological balance.\u003cbr\u003e\nCJC-1295 without DAC enhances GH release without significantly affecting prolactin levels.\u003cbr\u003e\nResearch indicates that combining CJC-1295 without DAC with a GH secretagogue like Ipamorelin may amplify its effects.\u003c\/p\u003e\n\n\u003cp\u003eCJC-1295 and Muscle Growth \u0026amp; Recovery\u003cbr\u003e\nAs an essential regulator of GH, CJC-1295 has been studied for its potential role in enhancing muscle repair, protein synthesis, and strength development. Key findings include:\u003c\/p\u003e\n\n\u003cp\u003eIncreased lean muscle mass and reduction in fat mass.\u003cbr\u003e\nFaster muscle recovery after intense exercise or injury.\u003cbr\u003e\nPotential benefits in age-related muscle wasting conditions.\u003c\/p\u003e\n\n\u003cp\u003eCJC-1295 and Fat Metabolism\u003cbr\u003e\nGrowth hormone is known to influence lipid metabolism, and research on CJC-1295 suggests:\u003c\/p\u003e\n\n\u003cp\u003eEnhanced lipolysis, leading to improved fat loss.\u003cbr\u003e\nRegulation of adipose tissue distribution, supporting a leaner physique.\u003cbr\u003e\nIncreased metabolic rate, contributing to better energy balance.\u003c\/p\u003e\n\n\u003cp\u003eCJC-1295 and Anti-Aging Research\u003cbr\u003e\nCJC-1295 Without DAC has been explored for its role in longevity and cellular repair. Research indicates:\u003c\/p\u003e\n\n\u003cp\u003eEnhanced collagen production, potentially improving skin elasticity and joint health.\u003cbr\u003e\nCellular regeneration and neuroprotection, which may benefit cognitive function.\u003cbr\u003e\nImproved sleep cycles due to its influence on deep sleep stages.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂\u003cbr\u003e\nMolecular Weight: 3367.9 g\/mol\u003cbr\u003e\nCAS Registry Number: 863288-34-0\u003cbr\u003e\nPurity: 99% HPLC\u003c\/p\u003e\n\n\u003cp\u003eRESEARCH USE ONLY\u003cbr\u003e\nCJC-1295 Without DAC is strictly intended for research and laboratory purposes. It is not for human or veterinary use and is not intended for therapeutic or diagnostic applications.\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561348329,"sku":"PS025","price":55.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/CJC-1295-WITHOUT-DAC-5MG-scaled.jpg?v=1778509492"},{"product_id":"hgh-fragment-176-191-5mg","title":"HGH-Fragment 176-191 5mg","description":"","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561577705,"sku":"PS016","price":55.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/FRAGMENT-5MG-scaled.jpg?v=1778509499"},{"product_id":"hgh-fragment-176-191-2mg","title":"HGH-Fragment 176-191 2mg","description":"","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561610473,"sku":"PS015","price":40.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/FRAGMENT-2MG-scaled.jpg?v=1778509499"}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/collections\/Peptides_Verse_Collection_image_02_jpg.jpg?v=1779217065","url":"https:\/\/f1kjgr-r5.myshopify.com\/collections\/ghrh-ghrp-peptides.oembed","provider":"Peptides Verse","version":"1.0","type":"link"}