{"title":"Other Research Compounds","description":"","products":[{"product_id":"selank-10mg","title":"Selank 10MG","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nSelank is a synthetic analogue of tuftsin, a naturally occurring immunomodulatory peptide. Originally developed in Russia, it has been extensively studied for its anxiolytic (anti-anxiety), nootropic (cognitive-enhancing), and immune-boosting properties.\u003cbr\u003e\nResearch suggests that Selank may:\u003c\/p\u003e\n\n\u003cp\u003eReduce anxiety without causing sedation or addiction.\u003cbr\u003e\nEnhance memory, learning, and cognitive function.\u003cbr\u003e\nModulate immune system responses, aiding in stress-induced immune dysfunction.\u003cbr\u003e\nRegulate inflammatory cytokines, particularly by suppressing IL-6, a key marker of inflammation.\u003cbr\u003e\nIncrease brain-derived neurotrophic factor (BDNF), supporting neuroplasticity and brain health.\u003c\/p\u003e\n\n\u003cp\u003eDue to its effects on the GABAergic system, Selank is considered a potential alternative to benzodiazepines for treating anxiety-related disorders—without the risk of dependence or withdrawal.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nSelank and Anxiety Reduction\u003cbr\u003e\nSelank interacts with the GABAergic system, similar to benzodiazepines, but with key distinctions:\u003c\/p\u003e\n\n\u003cp\u003eEnhances GABA receptor sensitivity, promoting a calming effect.\u003cbr\u003e\nDoes not cause dependence, withdrawal symptoms, or cognitive impairment, unlike traditional anxiolytics.\u003cbr\u003e\nIncreases the effectiveness of diazepam (Valium) when combined, suggesting a synergistic mechanism.\u003c\/p\u003e\n\n\u003cp\u003eClinical trials conducted in Russia demonstrated that Selank:\u003c\/p\u003e\n\n\u003cp\u003eSignificantly reduced anxiety and improved mood in patients with generalized anxiety disorder (GAD) and neurasthenia.\u003c\/p\u003e\n\n\u003cp\u003eThese findings highlight Selank’s potential for treating anxiety disorders without the sedation or addiction risksassociated with benzodiazepines.\u003cbr\u003e\nSelank and Cognitive Enhancement\u003cbr\u003e\nSelank has been shown to improve learning, memory retention, and recall through multiple mechanisms:\u003c\/p\u003e\n\n\u003cp\u003eEnhances hippocampal gene expression, supporting neuroplasticity.\u003cbr\u003e\nIncreases neuropeptides that promote long-term memory formation.\u003cbr\u003e\nProtects against cognitive decline after brain injury or stress exposure.\u003c\/p\u003e\n\n\u003cp\u003eAnimal studies indicate that Selank enhances cognitive function even in subjects without anxiety, suggesting direct nootropic effects.\u003cbr\u003e\nSelank and Immune System Modulation\u003cbr\u003e\nSelank is unique among nootropic peptides due to its immune-modulating properties:\u003c\/p\u003e\n\n\u003cp\u003eSuppresses IL-6, a pro-inflammatory cytokine associated with anxiety and depression.\u003cbr\u003e\nRegulates T-helper cell activity, helping to maintain immune balance.\u003cbr\u003e\nDemonstrates antiviral potential, possibly aiding recovery from respiratory infections.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest that Selank may benefit individuals with stress-related immune suppression.\u003cbr\u003e\nSelank and Pain Perception\u003cbr\u003e\nSelank influences the endogenous opioid system by:\u003c\/p\u003e\n\n\u003cp\u003ePreventing the breakdown of enkephalins, the body’s natural pain-killing peptides.\u003cbr\u003e\nReducing stress-related hyperalgesia, a condition where anxiety or chronic stress amplifies pain sensitivity.\u003c\/p\u003e\n\n\u003cp\u003eThis mechanism mirrors the effects of opioid receptor modulators and certain antidepressants, making Selank a potential alternative treatment for chronic pain conditions.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₃₃H₅₇N₁₁O₉\u003cbr\u003e\nMolecular Weight: 751.887 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro\u003cbr\u003e\nCAS Registry Number: 129954-34-3\u003cbr\u003e\nPubChem Identifier: 11765600\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eVolkova, A. et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front. Pharmacol. (2016).\u003cbr\u003e\nKasian, A. et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology (2017).\u003cbr\u003e\nZozulya, A. A. et al. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull. Exp. Biol. Med. (2001).\u003cbr\u003e\nSokolov, O. Y. et al. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull. Exp. Biol. Med. (2003).\u003cbr\u003e\nUchakina, O. N. et al. Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders. Zh. Nevrol. Psikhiatr. (2008).\u003cbr\u003e\nKolomin, T. et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul. Pept. (2011).\u003cbr\u003e\nSemenova, T. et al. Effect of Selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull. Exp. Biol. Med. (2014).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560168681,"sku":"PS033-1","price":65.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/SELANK.png?v=1778509462"},{"product_id":"semax-10mg","title":"Semax 10mg","description":"OVERVIEW\nSemax is a synthetic derivative of adrenocorticotropic hormone (ACTH), originally developed in Russia for its neuroprotective, cognitive-enhancing, and immune-boosting properties. Research suggests that Semax may:\n\nIncrease brain-derived neurotrophic factor (BDNF), supporting neuroplasticity and learning.\nEnhance immune function and reduce inflammation.\nProtect neurons from ischemic damage, aiding in stroke and traumatic brain injury (TBI) recovery.\nImprove cardiovascular function, potentially enhancing blood circulation.\nAct as an antidepressant and anxiolytic (anti-anxiety agent) by modulating serotonin, dopamine, and BDNF levels.\n\nDue to its ability to support mental performance, reduce stress, and promote neurological recovery, Semax is widely researched in neurology, cognitive enhancement, and immune regulation.\nRESEARCH\nSemax and Stroke Recovery\nSemax has been extensively studied for its neuroprotective effects in stroke and traumatic brain injury (TBI).\n\nIn rat models of stroke, Semax activated 24 genes linked to vascular function, promoting neurogenesis and protecting against ischemic damage.\nClinical trials in stroke patients showed that those receiving Semax experienced faster motor function recovery and improved neurological outcomes.\nBDNF elevation facilitated brain plasticity and functional rehabilitation.\n\nThese findings suggest Semax could be a promising treatment for post-stroke recovery and neurodegenerative conditions.\nSemax and Cognitive Enhancement\nSemax has been studied for its potential as a nootropic (cognitive enhancer):\n\nIncreases BDNF levels in the hippocampus, improving learning and memory formation.\nEnhances prefrontal cortex activity, potentially boosting problem-solving skills and attention span.\nProtects against cognitive decline, possibly preventing age-related memory loss.\n\nThese neuroprotective and cognitive-enhancing effects make Semax a promising compound for cognitive longevity and brain health.\nSemax and the Default Mode Network (DMN)\n\nFunctional MRI studies suggest that Semax activates the Default Mode Network (DMN), a system responsible for:\n\nSocial cognition\nEnvironmental awareness\nResting-state brain activity\n\n\nEnhanced DMN function is linked to better focus, cognitive flexibility, and mental clarity.\nDMN disruptions are associated with neurodegenerative diseases like Alzheimer’s, suggesting Semax may play a neuroprotective role.\n\nSemax and Depression\/Anxiety\nSemax may offer antidepressant and anxiolytic effects by modulating serotonin, dopamine, and BDNF levels.\n\nAnimal studies show that Semax increases BDNF production, reducing depressive symptoms.\nUnlike SSRIs, Semax may work faster by directly increasing neurotrophic support, rather than altering serotonin levels alone.\nPotential as an adjunct therapy with antidepressants for enhanced efficacy.\n\nSemax and Pain Management\nResearch suggests Semax may help regulate pain perception by influencing the opioid system:\n\nPrevents the breakdown of enkephalins, the brain’s natural painkillers.\nMay provide an alternative approach for chronic pain management.\n\nSemax and Immune System Support\n\nSuppresses IL-6, a key inflammatory cytokine involved in stress response and immune dysfunction.\nEnhances T-helper cell activity, leading to better immune system balance.\nPotential antiviral properties, suggesting possible applications in infection recovery.\n\nSTRUCTURE\n\nMolecular Formula: C₃₉H₅₄N₁₀O₁₀S\nMolecular Weight: 854.99 g\/mol\nAmino Acid Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro\nCAS Registry Number: 80714-61-0\nPubChem Identifier: 122178\nSynonyms: Pro-Gly-Pro-ACTH, ACTH(4-10) analog\n\nCITATIONS\n\nLebedeva, I. S. et al. Effects of Semax on the Default Mode Network of the Brain. Bulletin of Experimental Biology and Medicine (2018).\nMars, R. B. et al. On the relationship between the default mode network and the social brain. Front. Hum. Neurosci. (2012).\nMedvedeva, E. V. et al. The peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia. BMC Genomics (2014).\nGusev, E. I. et al. The efficacy of Semax in the treatment of patients at different stages of ischemic stroke.Zhurnal Nevrologii i Psikhiatrii (2018).\nAgapova, T. I. et al. Effect of Semax on BDNF and NGF gene expression in the rat hippocampus and frontal cortex. Molecular Genetics, Microbiology, and Virology (2008).\nScantlebury, M. H. et al. Adrenocorticotropic Hormone Protects Learning and Memory Function in Epileptic Mice. Neuroscience Letters (2017).\nDeltheil, T. et al. Behavioral and serotonergic consequences of increasing hippocampus BDNF protein levels.Neuropharmacology (2008).\nBobyntsev, I. I. et al. Influence of ACTG4-7-PGP (Semax) on the morphofunctional state of hepatocytes in chronic stress. Bulletin of Experimental Biology and Medicine (2017).\nBobyntsev, I. I. et al. The effect of ACTH-4-7-PGP peptide on lipid peroxidation and stress response in rats.Research Gate (2015).","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560201449,"sku":"PS034-1","price":80.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Semax-5mg-scaled.jpg?v=1778509460"},{"product_id":"kisspeptin-10-10mg","title":"Kisspeptin-10 10mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nKisspeptin-10 (KP-10) is a naturally occurring peptide that plays a critical role in reproductive hormone regulation. It serves as the primary trigger for the release of gonadotropin-releasing hormone (GnRH), which regulates key reproductive hormones such as testosterone, estrogen, and luteinizing hormone (LH).\u003cbr\u003e\nBeyond its well-established role in reproductive function, emerging research suggests Kisspeptin-10 may also contribute to:\u003c\/p\u003e\n\n\u003cp\u003eEnhancing fertility and reproductive health\u003cbr\u003e\nIncreasing testosterone levels in males\u003cbr\u003e\nRegulating mood, motivation, and behavior\u003cbr\u003e\nModulating energy balance and metabolism\u003cbr\u003e\nSuppressing tumor growth and cancer metastasis\u003c\/p\u003e\n\n\u003cp\u003eThese potential benefits make KP-10 a promising candidate for therapeutic applications in reproductive medicine, endocrinology, neurology, and oncology.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nReproductive Hormone Regulation\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin-10 initiates the release of GnRH, which stimulates LH and FSH secretion from the pituitary gland.\u003cbr\u003e\nThis regulatory function makes it essential for puberty onset, fertility, and overall reproductive function.\u003cbr\u003e\nPotential application: Treatment of delayed puberty, hypogonadism, and infertility.\u003c\/p\u003e\n\n\u003cp\u003eTestosterone Enhancement\u003c\/p\u003e\n\n\u003cp\u003eClinical studies show that KP-10 significantly increases testosterone levels in men within 90 minutes of administration.\u003cbr\u003e\nThis occurs by modulating LH pulse frequency, which fine-tunes the natural release of sex hormones.\u003cbr\u003e\nPotential application: Hormonal therapy and fertility enhancement in males.\u003c\/p\u003e\n\n\u003cp\u003eMood, Motivation, and Libido\u003c\/p\u003e\n\n\u003cp\u003eResearch links Kisspeptin to brain regions involved in reward-seeking behavior, motivation, and emotional regulation.\u003cbr\u003e\nA clinical study on 29 men found that KP-10 administration enhanced limbic brain activity, suggesting benefits in treating low libido and mood disorders.\u003cbr\u003e\nPotential application: Treatment for hypoactive sexual desire disorder (HSDD) and mood-related conditions.\u003c\/p\u003e\n\n\u003cp\u003eEnergy Balance and Metabolism\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin neurons are highly sensitive to nutritional status, influencing GnRH release based on energy availability.\u003cbr\u003e\nStudies in genetically modified mice lacking Kiss1 receptors showed weight gain and reduced energy expenditure, indicating a role in obesity regulation.\u003cbr\u003e\nPotential application: Obesity management and metabolic health support.\u003c\/p\u003e\n\n\u003cp\u003eAnti-Cancer Research\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin-10 has been linked to tumor suppression by reducing metastatic spread in various cancers.\u003cbr\u003e\nA groundbreaking study found that KP-10 suppressed melanoma metastasis by 95%.\u003cbr\u003e\nAltered kisspeptin levels have also been observed in breast, prostate, bladder, ovarian, and thyroid cancers, suggesting a role in tumor migration suppression.\u003cbr\u003e\nPotential application: Development of kisspeptin-based cancer therapies.\u003c\/p\u003e\n\n\u003cp\u003eMemory and Cognitive Function\u003c\/p\u003e\n\n\u003cp\u003eResearch suggests Kisspeptin analogs may enhance memory retention and cognitive flexibility.\u003cbr\u003e\nStudies in mice indicate that KP-10 counteracts learning impairments associated with alcohol exposure.\u003cbr\u003e\nPotential application: Neurological research and cognitive function support.\u003c\/p\u003e\n\n\u003cp\u003eKidney and Cardiovascular Health\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin receptors have been identified in the kidneys, where they support glomerular development and function.\u003cbr\u003e\nKP-10 has been linked to blood vessel function and cardiac output regulation, making it a potential therapeutic target for cardiovascular diseases.\u003cbr\u003e\nPotential application: Cardiovascular health and kidney disease treatment.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eAmino Acid Sequence: YNWNSFGLRF\u003cbr\u003e\nMolecular Formula: C₆₃H₈₃N₁₇O₁₄\u003cbr\u003e\nMolecular Weight: 1302.4 g\/mol\u003cbr\u003e\nCAS Registry Number: 388138-21-4\u003cbr\u003e\nSynonyms: KISS-1, Protein KISS-1, Metastin, KP-10 Peptide\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eW. S. Dhillo et al. Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males. J. Clin. Endocrinol. Metab. (2005).\u003cbr\u003e\nJ. T. George et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J. Clin. Endocrinol. Metab. (2011).\u003cbr\u003e\nC. J. L. Harter, G. S. Kavanagh, and J. T. Smith. The role of kisspeptin neurons in reproduction and metabolism. J. Endocrinol. (2018).\u003cbr\u003e\nE. J. Mead et al. Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer, and the cardiovascular system. Br. J. Pharmacol. (2007).\u003cbr\u003e\nT. Ly, S. Harihar, and D. R. Welch. KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer Metastasis Rev. (2020).\u003cbr\u003e\nP. Pazarci et al. The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croat. Med. J. (2020).\u003cbr\u003e\nE. Gibula-Tarlowska and J. H. Kotlinska. Kissorphin improves spatial memory and cognitive flexibility impairment induced by ethanol treatment in the Barnes maze task in rats. Behav. Pharmacol. (2020).\u003cbr\u003e\nA. N. Comninos et al. Kisspeptin modulates sexual and emotional brain processing in humans. J. Clin. Invest. (2017).\u003cbr\u003e\nM. Bhattacharya and A. V. Babwah. Kisspeptin: Beyond the Brain. Endocrinology (2015).\u003cbr\u003e\nAntitumor efficacy of Kisspeptin in human malignant mesothelioma cells. PubMed Central (PMC).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560266985,"sku":"PS052-1","price":99.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/kisspeptin-10-scaled.jpg?v=1778509462"},{"product_id":"reconstitution-solution","title":"Reconstitution Solution","description":"Bacteriostatic Water (Bac Water)\nOverview\nBacteriostatic Water is sterile water containing 0.9% benzyl alcohol, used for diluting peptides and medications before injection.\nKey Benefits:\n✔ Prevents bacterial growth in multi-use vials\n✔ Prolongs shelf-life of reconstituted peptides\n✔ Safe for subcutaneous and intramuscular injections\nCitations:\n\nU.S. Pharmacopeia, “Bacteriostatic Water for Injection,” USP 43-NF38, 2020.","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560398057,"sku":"PS060","price":8.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/RECONSTITION-SOLUTION-3ML.png?v=1778509470"},{"product_id":"kisspeptin-10-5mg","title":"Kisspeptin-10 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nKisspeptin-10 (KP-10) is a naturally occurring peptide that plays a critical role in reproductive hormone regulation. It serves as the primary trigger for the release of gonadotropin-releasing hormone (GnRH), which regulates key reproductive hormones such as testosterone, estrogen, and luteinizing hormone (LH).\u003cbr\u003e\nBeyond its well-established role in reproductive function, emerging research suggests Kisspeptin-10 may also contribute to:\u003c\/p\u003e\n\n\u003cp\u003eEnhancing fertility and reproductive health\u003cbr\u003e\nIncreasing testosterone levels in males\u003cbr\u003e\nRegulating mood, motivation, and behavior\u003cbr\u003e\nModulating energy balance and metabolism\u003cbr\u003e\nSuppressing tumor growth and cancer metastasis\u003c\/p\u003e\n\n\u003cp\u003eThese potential benefits make KP-10 a promising candidate for therapeutic applications in reproductive medicine, endocrinology, neurology, and oncology.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nReproductive Hormone Regulation\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin-10 initiates the release of GnRH, which stimulates LH and FSH secretion from the pituitary gland.\u003cbr\u003e\nThis regulatory function makes it essential for puberty onset, fertility, and overall reproductive function.\u003cbr\u003e\nPotential application: Treatment of delayed puberty, hypogonadism, and infertility.\u003c\/p\u003e\n\n\u003cp\u003eTestosterone Enhancement\u003c\/p\u003e\n\n\u003cp\u003eClinical studies show that KP-10 significantly increases testosterone levels in men within 90 minutes of administration.\u003cbr\u003e\nThis occurs by modulating LH pulse frequency, which fine-tunes the natural release of sex hormones.\u003cbr\u003e\nPotential application: Hormonal therapy and fertility enhancement in males.\u003c\/p\u003e\n\n\u003cp\u003eMood, Motivation, and Libido\u003c\/p\u003e\n\n\u003cp\u003eResearch links Kisspeptin to brain regions involved in reward-seeking behavior, motivation, and emotional regulation.\u003cbr\u003e\nA clinical study on 29 men found that KP-10 administration enhanced limbic brain activity, suggesting benefits in treating low libido and mood disorders.\u003cbr\u003e\nPotential application: Treatment for hypoactive sexual desire disorder (HSDD) and mood-related conditions.\u003c\/p\u003e\n\n\u003cp\u003eEnergy Balance and Metabolism\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin neurons are highly sensitive to nutritional status, influencing GnRH release based on energy availability.\u003cbr\u003e\nStudies in genetically modified mice lacking Kiss1 receptors showed weight gain and reduced energy expenditure, indicating a role in obesity regulation.\u003cbr\u003e\nPotential application: Obesity management and metabolic health support.\u003c\/p\u003e\n\n\u003cp\u003eAnti-Cancer Research\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin-10 has been linked to tumor suppression by reducing metastatic spread in various cancers.\u003cbr\u003e\nA groundbreaking study found that KP-10 suppressed melanoma metastasis by 95%.\u003cbr\u003e\nAltered kisspeptin levels have also been observed in breast, prostate, bladder, ovarian, and thyroid cancers, suggesting a role in tumor migration suppression.\u003cbr\u003e\nPotential application: Development of kisspeptin-based cancer therapies.\u003c\/p\u003e\n\n\u003cp\u003eMemory and Cognitive Function\u003c\/p\u003e\n\n\u003cp\u003eResearch suggests Kisspeptin analogs may enhance memory retention and cognitive flexibility.\u003cbr\u003e\nStudies in mice indicate that KP-10 counteracts learning impairments associated with alcohol exposure.\u003cbr\u003e\nPotential application: Neurological research and cognitive function support.\u003c\/p\u003e\n\n\u003cp\u003eKidney and Cardiovascular Health\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin receptors have been identified in the kidneys, where they support glomerular development and function.\u003cbr\u003e\nKP-10 has been linked to blood vessel function and cardiac output regulation, making it a potential therapeutic target for cardiovascular diseases.\u003cbr\u003e\nPotential application: Cardiovascular health and kidney disease treatment.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eAmino Acid Sequence: YNWNSFGLRF\u003cbr\u003e\nMolecular Formula: C₆₃H₈₃N₁₇O₁₄\u003cbr\u003e\nMolecular Weight: 1302.4 g\/mol\u003cbr\u003e\nCAS Registry Number: 388138-21-4\u003cbr\u003e\nSynonyms: KISS-1, Protein KISS-1, Metastin, KP-10 Peptide\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eW. S. Dhillo et al. Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males. J. Clin. Endocrinol. Metab. (2005).\u003cbr\u003e\nJ. T. George et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J. Clin. Endocrinol. Metab. (2011).\u003cbr\u003e\nC. J. L. Harter, G. S. Kavanagh, and J. T. Smith. The role of kisspeptin neurons in reproduction and metabolism. J. Endocrinol. (2018).\u003cbr\u003e\nE. J. Mead et al. Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer, and the cardiovascular system. Br. J. Pharmacol. (2007).\u003cbr\u003e\nT. Ly, S. Harihar, and D. R. Welch. KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer Metastasis Rev. (2020).\u003cbr\u003e\nP. Pazarci et al. The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croat. Med. J. (2020).\u003cbr\u003e\nE. Gibula-Tarlowska and J. H. Kotlinska. Kissorphin improves spatial memory and cognitive flexibility impairment induced by ethanol treatment in the Barnes maze task in rats. Behav. Pharmacol. (2020).\u003cbr\u003e\nA. N. Comninos et al. Kisspeptin modulates sexual and emotional brain processing in humans. J. Clin. Invest. (2017).\u003cbr\u003e\nM. Bhattacharya and A. V. Babwah. Kisspeptin: Beyond the Brain. Endocrinology (2015).\u003cbr\u003e\nAntitumor efficacy of Kisspeptin in human malignant mesothelioma cells. PubMed Central (PMC).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560660201,"sku":"PS052","price":49.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Kisspeptin-10-5mg-scaled.jpg?v=1778509473"},{"product_id":"semax-5mg","title":"Semax 5mg","description":"OVERVIEW\nSemax is a synthetic derivative of adrenocorticotropic hormone (ACTH), originally developed in Russia for its neuroprotective, cognitive-enhancing, and immune-boosting properties. Research suggests that Semax may:\n\nIncrease brain-derived neurotrophic factor (BDNF), supporting neuroplasticity and learning.\nEnhance immune function and reduce inflammation.\nProtect neurons from ischemic damage, aiding in stroke and traumatic brain injury (TBI) recovery.\nImprove cardiovascular function, potentially enhancing blood circulation.\nAct as an antidepressant and anxiolytic (anti-anxiety agent) by modulating serotonin, dopamine, and BDNF levels.\n\nDue to its ability to support mental performance, reduce stress, and promote neurological recovery, Semax is widely researched in neurology, cognitive enhancement, and immune regulation.\nRESEARCH\nSemax and Stroke Recovery\nSemax has been extensively studied for its neuroprotective effects in stroke and traumatic brain injury (TBI).\n\nIn rat models of stroke, Semax activated 24 genes linked to vascular function, promoting neurogenesis and protecting against ischemic damage.\nClinical trials in stroke patients showed that those receiving Semax experienced faster motor function recovery and improved neurological outcomes.\nBDNF elevation facilitated brain plasticity and functional rehabilitation.\n\nThese findings suggest Semax could be a promising treatment for post-stroke recovery and neurodegenerative conditions.\nSemax and Cognitive Enhancement\nSemax has been studied for its potential as a nootropic (cognitive enhancer):\n\nIncreases BDNF levels in the hippocampus, improving learning and memory formation.\nEnhances prefrontal cortex activity, potentially boosting problem-solving skills and attention span.\nProtects against cognitive decline, possibly preventing age-related memory loss.\n\nThese neuroprotective and cognitive-enhancing effects make Semax a promising compound for cognitive longevity and brain health.\nSemax and the Default Mode Network (DMN)\n\nFunctional MRI studies suggest that Semax activates the Default Mode Network (DMN), a system responsible for:\n\nSocial cognition\nEnvironmental awareness\nResting-state brain activity\n\n\nEnhanced DMN function is linked to better focus, cognitive flexibility, and mental clarity.\nDMN disruptions are associated with neurodegenerative diseases like Alzheimer’s, suggesting Semax may play a neuroprotective role.\n\nSemax and Depression\/Anxiety\nSemax may offer antidepressant and anxiolytic effects by modulating serotonin, dopamine, and BDNF levels.\n\nAnimal studies show that Semax increases BDNF production, reducing depressive symptoms.\nUnlike SSRIs, Semax may work faster by directly increasing neurotrophic support, rather than altering serotonin levels alone.\nPotential as an adjunct therapy with antidepressants for enhanced efficacy.\n\nSemax and Pain Management\nResearch suggests Semax may help regulate pain perception by influencing the opioid system:\n\nPrevents the breakdown of enkephalins, the brain’s natural painkillers.\nMay provide an alternative approach for chronic pain management.\n\nSemax and Immune System Support\n\nSuppresses IL-6, a key inflammatory cytokine involved in stress response and immune dysfunction.\nEnhances T-helper cell activity, leading to better immune system balance.\nPotential antiviral properties, suggesting possible applications in infection recovery.\n\nSTRUCTURE\n\nMolecular Formula: C₃₉H₅₄N₁₀O₁₀S\nMolecular Weight: 854.99 g\/mol\nAmino Acid Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro\nCAS Registry Number: 80714-61-0\nPubChem Identifier: 122178\nSynonyms: Pro-Gly-Pro-ACTH, ACTH(4-10) analog\n\nCITATIONS\n\nLebedeva, I. S. et al. Effects of Semax on the Default Mode Network of the Brain. Bulletin of Experimental Biology and Medicine (2018).\nMars, R. B. et al. On the relationship between the default mode network and the social brain. Front. Hum. Neurosci. (2012).\nMedvedeva, E. V. et al. The peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia. BMC Genomics (2014).\nGusev, E. I. et al. The efficacy of Semax in the treatment of patients at different stages of ischemic stroke.Zhurnal Nevrologii i Psikhiatrii (2018).\nAgapova, T. I. et al. Effect of Semax on BDNF and NGF gene expression in the rat hippocampus and frontal cortex. Molecular Genetics, Microbiology, and Virology (2008).\nScantlebury, M. H. et al. Adrenocorticotropic Hormone Protects Learning and Memory Function in Epileptic Mice. Neuroscience Letters (2017).\nDeltheil, T. et al. Behavioral and serotonergic consequences of increasing hippocampus BDNF protein levels.Neuropharmacology (2008).\nBobyntsev, I. I. et al. Influence of ACTG4-7-PGP (Semax) on the morphofunctional state of hepatocytes in chronic stress. Bulletin of Experimental Biology and Medicine (2017).\nBobyntsev, I. I. et al. The effect of ACTH-4-7-PGP peptide on lipid peroxidation and stress response in rats.Research Gate (2015).","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561086185,"sku":"PS034","price":40.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Semax-5mg-scaled_fb250cfd-4a21-40b2-af2e-f88fe1d94810.jpg?v=1778509485"},{"product_id":"selank-5mg","title":"Selank 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nSelank is a synthetic analogue of tuftsin, a naturally occurring immunomodulatory peptide. Originally developed in Russia, it has been extensively studied for its anxiolytic (anti-anxiety), nootropic (cognitive-enhancing), and immune-boosting properties.\u003cbr\u003e\nResearch suggests that Selank may:\u003c\/p\u003e\n\n\u003cp\u003eReduce anxiety without causing sedation or addiction.\u003cbr\u003e\nEnhance memory, learning, and cognitive function.\u003cbr\u003e\nModulate immune system responses, aiding in stress-induced immune dysfunction.\u003cbr\u003e\nRegulate inflammatory cytokines, particularly by suppressing IL-6, a key marker of inflammation.\u003cbr\u003e\nIncrease brain-derived neurotrophic factor (BDNF), supporting neuroplasticity and brain health.\u003c\/p\u003e\n\n\u003cp\u003eDue to its effects on the GABAergic system, Selank is considered a potential alternative to benzodiazepines for treating anxiety-related disorders—without the risk of dependence or withdrawal.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nSelank and Anxiety Reduction\u003cbr\u003e\nSelank interacts with the GABAergic system, similar to benzodiazepines, but with key distinctions:\u003c\/p\u003e\n\n\u003cp\u003eEnhances GABA receptor sensitivity, promoting a calming effect.\u003cbr\u003e\nDoes not cause dependence, withdrawal symptoms, or cognitive impairment, unlike traditional anxiolytics.\u003cbr\u003e\nIncreases the effectiveness of diazepam (Valium) when combined, suggesting a synergistic mechanism.\u003c\/p\u003e\n\n\u003cp\u003eClinical trials conducted in Russia demonstrated that Selank:\u003c\/p\u003e\n\n\u003cp\u003eSignificantly reduced anxiety and improved mood in patients with generalized anxiety disorder (GAD) and neurasthenia.\u003c\/p\u003e\n\n\u003cp\u003eThese findings highlight Selank’s potential for treating anxiety disorders without the sedation or addiction risksassociated with benzodiazepines.\u003cbr\u003e\nSelank and Cognitive Enhancement\u003cbr\u003e\nSelank has been shown to improve learning, memory retention, and recall through multiple mechanisms:\u003c\/p\u003e\n\n\u003cp\u003eEnhances hippocampal gene expression, supporting neuroplasticity.\u003cbr\u003e\nIncreases neuropeptides that promote long-term memory formation.\u003cbr\u003e\nProtects against cognitive decline after brain injury or stress exposure.\u003c\/p\u003e\n\n\u003cp\u003eAnimal studies indicate that Selank enhances cognitive function even in subjects without anxiety, suggesting direct nootropic effects.\u003cbr\u003e\nSelank and Immune System Modulation\u003cbr\u003e\nSelank is unique among nootropic peptides due to its immune-modulating properties:\u003c\/p\u003e\n\n\u003cp\u003eSuppresses IL-6, a pro-inflammatory cytokine associated with anxiety and depression.\u003cbr\u003e\nRegulates T-helper cell activity, helping to maintain immune balance.\u003cbr\u003e\nDemonstrates antiviral potential, possibly aiding recovery from respiratory infections.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest that Selank may benefit individuals with stress-related immune suppression.\u003cbr\u003e\nSelank and Pain Perception\u003cbr\u003e\nSelank influences the endogenous opioid system by:\u003c\/p\u003e\n\n\u003cp\u003ePreventing the breakdown of enkephalins, the body’s natural pain-killing peptides.\u003cbr\u003e\nReducing stress-related hyperalgesia, a condition where anxiety or chronic stress amplifies pain sensitivity.\u003c\/p\u003e\n\n\u003cp\u003eThis mechanism mirrors the effects of opioid receptor modulators and certain antidepressants, making Selank a potential alternative treatment for chronic pain conditions.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₃₃H₅₇N₁₁O₉\u003cbr\u003e\nMolecular Weight: 751.887 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro\u003cbr\u003e\nCAS Registry Number: 129954-34-3\u003cbr\u003e\nPubChem Identifier: 11765600\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eVolkova, A. et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front. Pharmacol. (2016).\u003cbr\u003e\nKasian, A. et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology (2017).\u003cbr\u003e\nZozulya, A. A. et al. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull. Exp. Biol. Med. (2001).\u003cbr\u003e\nSokolov, O. Y. et al. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull. Exp. Biol. Med. (2003).\u003cbr\u003e\nUchakina, O. N. et al. Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders. Zh. Nevrol. Psikhiatr. (2008).\u003cbr\u003e\nKolomin, T. et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul. Pept. (2011).\u003cbr\u003e\nSemenova, T. et al. Effect of Selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull. Exp. Biol. Med. (2014).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561118953,"sku":"PS033","price":35.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Selank-5mg-scaled.jpg?v=1778509485"},{"product_id":"pt-141-10mg","title":"PT-141 10mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nPT-141, also known as Bremelanotide, is a synthetic derivative of alpha-melanocyte-stimulating hormone (α-MSH). Initially developed to treat sexual dysfunction in both men and women, it has also been explored for its immune-modulating properties and potential applications in hemorrhagic shock treatment.\u003cbr\u003e\nPT-141 functions as a melanocortin receptor (MC) agonist, primarily targeting MC-4R and MC-1R, which play roles in sexual arousal, immune function, and vascular regulation. Research suggests that PT-141 can:\u003c\/p\u003e\n\n\u003cp\u003eEnhance libido and sexual arousal.\u003cbr\u003e\nImprove erectile function in men and increase sexual desire in women.\u003cbr\u003e\nStimulate immune system activity.\u003cbr\u003e\nReduce inflammation and ischemic damage.\u003c\/p\u003e\n\n\u003cp\u003eUnlike traditional PDE5 inhibitors (e.g., Viagra, Cialis), which work by increasing blood flow, PT-141 acts directly on the central nervous system, making it a potential alternative for individuals with psychogenic sexual dysfunction.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nPT-141 and Sexual Arousal\u003cbr\u003e\nPT-141’s impact on sexual function is linked to its activation of the MC-4R receptor, found in the central nervous system and associated with sexual behavior and arousal.\u003c\/p\u003e\n\n\u003cp\u003eAnimal studies showed that MC-4R activation increased mating behavior in both male and female subjects.\u003cbr\u003e\nClinical trials in men with erectile dysfunction (ED)—including those unresponsive to sildenafil (Viagra)—revealed that one-third of participants achieved sufficient erections with PT-141.\u003cbr\u003e\nPre-menopausal women with hypoactive sexual desire disorder (HSDD) experienced:\u003c\/p\u003e\n\n\u003cp\u003eIncreased frequency of satisfying sexual events.\u003cbr\u003e\nReduced distress related to low sexual desire.\u003c\/p\u003e\n\n\n\n\u003cp\u003eBecause PT-141 acts via the brain and not the vascular system, it may be particularly effective for non-vascular causes of sexual dysfunction.\u003cbr\u003e\nPT-141 and Hemorrhagic Shock\u003cbr\u003e\nIn 2009, PT-141 was investigated for acute hemorrhage treatment, with research suggesting potential emergency medicine applications.\u003c\/p\u003e\n\n\u003cp\u003eThe MC-1R receptor plays a key role in vascular response and blood flow regulation.\u003cbr\u003e\nStudies indicated that PT-141 enhanced vascular integrity and reduced ischemic damage in hemorrhagic shock models.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest PT-141 or its derivatives could be explored for trauma and critical care medicine.\u003cbr\u003e\nPT-141 and Immune System Modulation\u003cbr\u003e\nPT-141 also targets the MC-1R receptor, which is involved in immune regulation.\u003c\/p\u003e\n\n\u003cp\u003eAnimal studies suggest PT-141 may exhibit:\u003c\/p\u003e\n\n\u003cp\u003eAnti-inflammatory properties.\u003cbr\u003e\nAntimicrobial effects, potentially aiding in infection control.\u003c\/p\u003e\n\n\n\u003cp\u003eMC-1R activation has been linked to immune system support in autoimmune conditions and inflammatory diseases.\u003c\/p\u003e\n\n\u003cp\u003eThis research highlights PT-141’s potential beyond sexual health, particularly in immune and inflammatory disorders.\u003cbr\u003e\nPT-141 and Cancer Research\u003cbr\u003e\nRecent studies suggest that PT-141 may influence DNA repair mechanisms:\u003c\/p\u003e\n\n\u003cp\u003eThe MC-1R receptor is involved in DNA damage repair pathways.\u003cbr\u003e\nIndividuals with MC-1R mutations have a higher risk of melanoma and skin cancer.\u003c\/p\u003e\n\n\u003cp\u003eOngoing research aims to determine whether PT-141 could help prevent certain cancers or support DNA repair in high-risk individuals.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₅₀H₆₈N₁₄O₁₀\u003cbr\u003e\nMolecular Weight: 1025.182 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)\u003cbr\u003e\nCAS Registry Number: 189691-06-3\u003cbr\u003e\nPubChem Identifier: 9941379\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eRosen, R. C. et al. Evaluation of the safety, pharmacokinetics, and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. International Journal of Impotence Research (2004).\u003cbr\u003e\nWessells, H. et al. PT-141 induces penile erection via brain and spinal melanocortin receptors. Neuroscience (2003).\u003cbr\u003e\nRössler, A.-S. et al. The melanocortin agonist, Melanotan II, enhances proceptive sexual behaviors in female rats. Pharmacology, Biochemistry, and Behavior (2006).\u003cbr\u003e\nSafarinejad, M. R. \u0026amp; Hosseini, S. Y. Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo-controlled study. Journal of Urology (2008).\u003cbr\u003e\nClayton, A. H. et al. Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Women’s Health (London, England) (2016).\u003cbr\u003e\nJi, H. et al. The Synthetic Melanocortin (CKPV)2 Exerts Anti-Fungal and Anti-Inflammatory Effects against Candida albicans Vaginitis via Inducing Macrophage M2 Polarization. PLoS ONE (2013).\u003cbr\u003e\nMaresca, V. et al. Skin phototype: a new perspective. Pigment Cell \u0026amp; Melanoma Research (2015).\u003cbr\u003e\nFeller, L. et al. Basal cell carcinoma, squamous cell carcinoma, and melanoma of the head and face. Head \u0026amp; Face Medicine (2016).\u003cbr\u003e\nMcMillan, T. R. et al. Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice. Experimental Physiology (2021).\u003cbr\u003e\nSpana, C. et al. Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials. Diabetes, Obesity, and Metabolism (2022).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561184489,"sku":"PS031","price":55.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/PT-141-10mg-scaled.jpg?v=1778509487"},{"product_id":"aod-9604-5mg","title":"AOD-9604 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nAOD9604 is a modified fragment of human growth hormone (hGH), specifically derived from hGH 176-191. It was originally developed as an anti-obesity agent and has been extensively studied for its fat-burning (lipolytic) properties.\u003cbr\u003e\nResearch indicates that AOD9604:\u003c\/p\u003e\n\n\u003cp\u003eStimulates fat breakdown (lipolysis).\u003cbr\u003e\nPrevents new fat accumulation (lipogenesis).\u003cbr\u003e\nDoes not increase IGF-1 or insulin levels, making it distinct from full-length hGH.\u003cbr\u003e\nDoes not trigger antibody production, suggesting potential long-term safety.\u003c\/p\u003e\n\n\u003cp\u003eBeyond fat metabolism, AOD9604 has been explored for its potential benefits in:\u003c\/p\u003e\n\n\u003cp\u003eHeart disease\u003cbr\u003e\nOsteoarthritis and cartilage repair\u003cbr\u003e\nMetabolic syndrome\u003c\/p\u003e\n\n\u003cp\u003eDue to these properties, AOD9604 has gained attention as a research candidate in weight management and regenerative medicine.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nAOD9604 and Fat Loss\u003cbr\u003e\nAOD9604 was initially developed to replicate the fat-burning effects of hGH without affecting other hormones.\u003c\/p\u003e\n\n\u003cp\u003eClinical Trials: A 12-week Phase 2b clinical trial conducted in Australia tested AOD9604 on 300 obese individuals.\u003cbr\u003e\nResults:\u003c\/p\u003e\n\n\u003cp\u003eParticipants receiving AOD9604 experienced three times more weight loss than the placebo group.\u003cbr\u003e\nConsistent fat reduction was observed throughout the study.\u003c\/p\u003e\n\n\n\u003cp\u003eMetabolic Safety:\u003c\/p\u003e\n\n\u003cp\u003eUnlike full-length hGH, AOD9604 does not elevate IGF-1 or insulin levels.\u003cbr\u003e\nThis makes it a potential safer alternative for individuals at risk of insulin resistance or diabetes.\u003c\/p\u003e\n\n\n\n\u003cp\u003eAOD9604: Mechanism Beyond Beta-3 Adrenergic Receptors\u003cbr\u003e\nEarly research suggested that AOD9604 works by activating beta-3 adrenergic receptors in fat cells, shifting them into fat-burning mode. However, experiments with genetically modified mice lacking these receptors still showed significant fat loss when administered AOD9604.\u003cbr\u003e\nThis suggests that AOD9604 may function through alternative pathways, possibly by:\u003c\/p\u003e\n\n\u003cp\u003eInducing apoptosis (programmed cell death) in white fat cells.\u003cbr\u003e\nRegulating lipid metabolism at the mitochondrial level, increasing energy expenditure.\u003c\/p\u003e\n\n\u003cp\u003eAOD9604 and Joint Health\u003cbr\u003e\nAnimal studies indicate that AOD9604 may have chondroprotective (cartilage-protecting) effects:\u003c\/p\u003e\n\n\u003cp\u003eIn osteoarthritis models (rats \u0026amp; rabbits):\u003c\/p\u003e\n\n\u003cp\u003eDirect intra-articular injections of AOD9604 improved joint function and reduced pain.\u003cbr\u003e\nHistological analysis revealed increased cartilage thickness and better structural integrity.\u003c\/p\u003e\n\n\n\u003cp\u003eSynergistic Effects:\u003c\/p\u003e\n\n\u003cp\u003eWhen combined with other osteoarthritis treatments, AOD9604 enhanced joint repair and functionbeyond standalone therapies.\u003c\/p\u003e\n\n\n\n\u003cp\u003eThese findings suggest potential applications in cartilage regeneration and osteoarthritis management.\u003cbr\u003e\nAOD9604 and Cardiovascular Health\u003cbr\u003e\nWhile fat reduction is inherently linked to heart health, studies suggest AOD9604 may provide direct metabolic benefits independent of weight loss.\u003c\/p\u003e\n\n\u003cp\u003eResearch indicates AOD9604 may enhance heart function in obese individuals.\u003cbr\u003e\nSimilar to metabolic drugs such as pioglitazone and acipimox, AOD9604 improves lipid metabolism, reducing cardiovascular risk factors.\u003c\/p\u003e\n\n\u003cp\u003eAOD9604 Safety Profile\u003cbr\u003e\nAOD9604 has demonstrated a strong safety profile in clinical research:\u003c\/p\u003e\n\n\u003cp\u003eNo significant adverse effects were reported in human trials.\u003cbr\u003e\nDoes not increase blood sugar, IGF-1, or insulin resistance.\u003cbr\u003e\nHighly bioavailable in both oral and subcutaneous forms.\u003c\/p\u003e\n\n\u003cp\u003eImportant Note:\u003cbr\u003e\nAOD9604 is currently for research use only and not approved for human consumption.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂\u003cbr\u003e\nMolecular Weight: 1815.12 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe\u003cbr\u003e\nDisulfide Bridge: Cys⁷-Cys¹⁵\u003cbr\u003e\nCAS Registry Number: 386264-39-7\u003cbr\u003e\nPubChem Identifier: 16131447\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eNg F. M. et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm. Res. (2000).\u003cbr\u003e\nStier H. et al. Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans. Journal of Endocrinology and Metabolism (2013).\u003cbr\u003e\nHeffernan M. et al. Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism in Obese Mice. Endocrinology (2001).\u003cbr\u003e\nZieba R. Obesity: A review of anti-obesity drugs in clinical development. Postepy Hig. Med. Dosw. (2007).\u003cbr\u003e\nKwon D. R. \u0026amp; Park G. Y. Effect of intra-articular injection of AOD9604 on osteoarthritis in rabbits. Ann. Clin. Lab. Sci. (2015).\u003cbr\u003e\nJensen M. D. Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors. Obesity (Silver Spring) (2006).\u003cbr\u003e\nNews-Medical.net Obesity drug AOD9604 highly successful in trials. (2004).\u003cbr\u003e\nCase Western Reserve University Molecular biology of peptide-derived fat loss agents. J. Mol. Endocrinol. (2015).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561217257,"sku":"PS030","price":50.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/AOD-9604-5MG-scaled.jpg?v=1778509489"},{"product_id":"melanotan-2-10mg","title":"Melanotan 2 10mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nMelanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed in the 1980s. It is known for its ability to:\u003c\/p\u003e\n\n\u003cp\u003eEnhance sexual arousal\u003cbr\u003e\nRegulate compulsive and addictive behaviors\u003cbr\u003e\nSuppress appetite and reduce fat storage\u003cbr\u003e\nIncrease melanin production, leading to a tanning effect\u003cbr\u003e\nPossibly influence neurodevelopmental conditions like autism when used in early stages\u003c\/p\u003e\n\n\u003cp\u003eMT-2 exerts its effects by binding to melanocortin receptors, primarily MC-1R and MC-4R, which are involved in pigmentation, metabolic regulation, and sexual function.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nMelanotan-2 and Melanocortin Receptor Activation\u003cbr\u003e\nMT-2 interacts with five known melanocortin receptors (MCRs), each serving distinct functions:\u003c\/p\u003e\n\n\u003cp\u003eMC-1R: Found in melanocytes, responsible for skin and hair pigmentation.\u003cbr\u003e\nMC-2R: Located in the adrenal glands, involved in cortisol and adrenal hormone secretion.\u003cbr\u003e\nMC-3R: Regulates appetite and energy metabolism.\u003cbr\u003e\nMC-4R: Plays a role in food intake, sexual behavior, and metabolic balance.\u003cbr\u003e\nMC-5R: Expressed in sweat glands and pancreatic islet cells, contributing to sebum production and insulin function.\u003c\/p\u003e\n\n\u003cp\u003eMT-2 and Autism Research\u003cbr\u003e\nRecent studies suggest that Melanotan-2 may influence autism-related behaviors in animal models. Research has shown that MT-2:\u003c\/p\u003e\n\n\u003cp\u003eEnhances oxytocin receptor expression in key brain regions.\u003cbr\u003e\nImproves social interaction and communication in autism spectrum disorder (ASD) models.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest that MT-2 may modulate oxytocin pathways, which play a role in social bonding and emotional regulation.\u003cbr\u003e\nMT-2 and Appetite Suppression\u003cbr\u003e\nMelanotan-2 has been found to reduce hunger and fat storage by activating MC-4R receptors in the hypothalamus. Research indicates that:\u003c\/p\u003e\n\n\u003cp\u003eMice treated with MT-2 significantly decreased food intake and changed their dietary preferences.\u003cbr\u003e\nMT-2 reduced cravings for high-fat foods, which are typically preferred in normal conditions.\u003cbr\u003e\nIt mimics leptin (the satiety hormone) but appears to be more effective in controlling hunger.\u003c\/p\u003e\n\n\u003cp\u003eThese findings highlight the potential of Melanotan-2 as a therapeutic tool for obesity management.\u003cbr\u003e\nMT-2 and Diabetes Management\u003cbr\u003e\nMT-2 has been studied for its potential role in blood sugar regulation, with findings suggesting that it can:\u003c\/p\u003e\n\n\u003cp\u003eLower blood glucose levels.\u003cbr\u003e\nReduce glucagon secretion, which helps regulate blood sugar.\u003cbr\u003e\nInhibit ketone body production, potentially preventing complications associated with diabetes.\u003c\/p\u003e\n\n\u003cp\u003eUnlike leptin, MT-2 can cross the blood-brain barrier in significant amounts, making it a more promising candidate for metabolic regulation.\u003cbr\u003e\nMT-2 and Addiction\/Impulse Control\u003cbr\u003e\nResearch suggests that Melanotan-2 may help regulate impulse control and reduce addictive behaviors, particularly in alcohol dependency. Studies have shown:\u003c\/p\u003e\n\n\u003cp\u003eRats treated with MT-2 significantly reduced alcohol consumption and instead chose water.\u003cbr\u003e\nMT-2 enhances the effects of naltrexone, a common anti-addiction medication, reducing binge drinking behaviors in mice.\u003c\/p\u003e\n\n\u003cp\u003eThese findings indicate that MT-2 may hold potential for treating alcoholism and other impulse-control disorders.\u003cbr\u003e\nMT-2 and Erectile Dysfunction\u003cbr\u003e\nOne of the earliest research areas for Melanotan-2 was its role in treating erectile dysfunction (ED). Key findings include:\u003c\/p\u003e\n\n\u003cp\u003eMT-2 proved effective in men who did not respond to sildenafil (Viagra).\u003cbr\u003e\nUp to 80% of men who failed Viagra treatment showed positive results with MT-2.\u003cbr\u003e\nIt works through central nervous system pathways, making it beneficial for both male and female sexual dysfunction.\u003c\/p\u003e\n\n\u003cp\u003eThese studies suggest that Melanotan-2 may be a viable alternative for individuals with treatment-resistant ED.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₅₀H₆₉N₁₅O₉\u003cbr\u003e\nMolecular Weight: 1024.198 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)\u003cbr\u003e\nCAS Registry Number: 121062-08-6\u003cbr\u003e\nPubChem Identifier: 92432\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eMinakova E. et al. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS ONE (2019).\u003cbr\u003e\nvan der Klaauw A. et al. Role of melanocortin signaling in the preference for dietary macronutrients in human beings. Lancet Lond. Engl. (2015).\u003cbr\u003e\nShimizu H., Inoue K., Mori M. The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. J. Endocrinol. (2007).\u003cbr\u003e\nBjørbaek C., Hollenberg A. N. Leptin and melanocortin signaling in the hypothalamus. Vitam. Horm. (2002).\u003cbr\u003e\nGuo F., Bakal K., Minokoshi Y., Hollenberg A. N. Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo. Endocrinology (2004).\u003cbr\u003e\nLee Y. H., Wang M. Y., Yu X. X., Unger R. H. Glucagon is the key factor in the development of diabetes.Diabetologia (2016).\u003cbr\u003e\nToda C. et al. Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009).\u003cbr\u003e\nYork D. A., Boghossian S., Park-York M. Melanocortin activity in the amygdala influences alcohol intake.Pharmacol. Biochem. Behav. (2011).\u003cbr\u003e\nNavarro M., Carvajal F., Lerma-Cabrera J. M., Cubero I., Picker M. J., Thiele T. E. Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL\/6J Mice. Alcohol. Clin. Exp. Res. (2015).\u003cbr\u003e\nWessells H. et al. MT-II Induces Penile Erection via Brain and Spinal Mechanisms. Annals of the New York Academy of Sciences (2003).\u003cbr\u003e\nWessells H. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind placebo-controlled crossover study. Nature (1998).\u003cbr\u003e\nLau J. K. Y. et al. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Scientific Reports (2021).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561381097,"sku":"PS024","price":40.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Melatonin-2-10mg-scaled.jpg?v=1778509493"},{"product_id":"lipo-c-b12-10ml","title":"Lipo-C (B12) 10ml","description":"Overview\nLipo-C (Lipotropic-C) is a compounded injectable formulation containing lipotropic agents, including Vitamin B12 (Cyanocobalamin or Methylcobalamin) and other fat-metabolizing compounds such as Methionine, Inositol, and Choline (MIC). These ingredients work synergistically to promote fat metabolism, energy production, and liver detoxification. Lipo-C injections are commonly used in medical weight loss programs and wellness treatments.\nMechanism of Action\nLipo-C enhances fat metabolism by supporting the liver’s ability to break down and eliminate fats more efficiently. The key components include:\n\nVitamin B12 (Cyanocobalamin or Methylcobalamin):\nEssential for energy production, red blood cell formation, and neurological function. B12 plays a role in fatty acid metabolism and helps prevent fatigue associated with weight loss.\nMethionine:\nAn essential amino acid that helps in fat mobilization and detoxification. It reduces fat accumulation in the liver and supports the production of glutathione, a key antioxidant.\nInositol:\nA lipotropic agent that aids in fat breakdown and cholesterol regulation. It also plays a role in insulin sensitivity, making it beneficial for metabolic health.\nCholine:\nA B-vitamin-like nutrient that supports fat metabolism, liver function, and neurotransmitter synthesis(acetylcholine). It helps transport fats out of the liver to be used as energy.\n\nResearch \u0026amp; Potential Benefits\n1. Fat Metabolism \u0026amp; Weight Loss\n\nLipo-C injections enhance fat breakdown and liver function, which may support weight loss when combined with diet and exercise.\nClinical studies suggest that B12 deficiency is associated with increased fat accumulation and metabolic dysfunction. (Obesity Research \u0026amp; Clinical Practice, 2017)\n\n2. Energy \u0026amp; Metabolic Support\n\nVitamin B12 plays a critical role in mitochondrial function, supporting energy levels and reducing fatigue.\nInositol and choline aid in cell signaling and neurotransmitter production, enhancing cognitive function and mood.\nA study in the American Journal of Clinical Nutrition found that B12 supplementation improved energy metabolism in individuals with deficiency. (AjCN, 2013)\n\n3. Liver Detoxification \u0026amp; Health\n\nMethionine and choline play a role in preventing fatty liver disease (NAFLD) by promoting hepatic fat metabolism.\nA study in the Journal of Hepatology suggests that choline deficiency contributes to liver dysfunction and fat accumulation. (Journal of Hepatology, 2018)\n\n4. Cardiovascular Health \u0026amp; Cholesterol Regulation\n\nCholine and inositol support healthy lipid levels, reducing the risk of high cholesterol and cardiovascular disease.\nResearch indicates that inositol supplementation may improve lipid profiles in individuals with metabolic syndrome. (European Journal of Clinical Nutrition, 2020)\n\nClinical Uses \u0026amp; Indications\nLipo-C injections are often used as part of medical weight loss programs and for metabolic support, including:\n✔ Weight management (fat metabolism support)\n✔ Boosting energy levels (B12 benefits)\n✔ Supporting liver detoxification (fatty liver prevention)\n✔ Improving mood and cognitive function (inositol\/choline role in neurotransmission)\nStructure \u0026amp; Composition\nLipo-C Injection Components:\n\nVitamin B12 (Cyanocobalamin or Methylcobalamin): 1,000 mcg\nMethionine: 25–50 mg\nInositol: 50–100 mg\nCholine: 50–100 mg\n\nCitations \u0026amp; References\n\nEl-Sohemy, A. et al. Association Between Vitamin B12 Status and Obesity in Adults Obesity Research \u0026amp; Clinical Practice, 2017.\nBor, M. et al. The role of inositol and choline in metabolic health European Journal of Clinical Nutrition, 2020.\nGuéant, J.L. et al. Vitamin B12 and Fatty Acid Metabolism American Journal of Clinical Nutrition, 2013.\nZeisel, S.H. et al. Choline Deficiency and Liver Function Journal of Hepatology, 2018.\n\nConclusion\nLipo-C injections offer a synergistic blend of lipotropic agents and Vitamin B12, promoting fat metabolism, energy production, and liver health. Research supports their potential benefits in weight management, metabolic health, and detoxification. However, Lipo-C should be used as part of a comprehensive health plan involving proper diet and exercise for optimal results.","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561544937,"sku":"PS017","price":60.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Lipo-C-10mg-scaled.jpg?v=1778509497"}],"url":"https:\/\/f1kjgr-r5.myshopify.com\/collections\/other-research-compounds.oembed","provider":"Peptides Verse","version":"1.0","type":"link"}