{"product_id":"aod-9604-5mg","title":"AOD-9604 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nAOD9604 is a modified fragment of human growth hormone (hGH), specifically derived from hGH 176-191. It was originally developed as an anti-obesity agent and has been extensively studied for its fat-burning (lipolytic) properties.\u003cbr\u003e\nResearch indicates that AOD9604:\u003c\/p\u003e\n\n\u003cp\u003eStimulates fat breakdown (lipolysis).\u003cbr\u003e\nPrevents new fat accumulation (lipogenesis).\u003cbr\u003e\nDoes not increase IGF-1 or insulin levels, making it distinct from full-length hGH.\u003cbr\u003e\nDoes not trigger antibody production, suggesting potential long-term safety.\u003c\/p\u003e\n\n\u003cp\u003eBeyond fat metabolism, AOD9604 has been explored for its potential benefits in:\u003c\/p\u003e\n\n\u003cp\u003eHeart disease\u003cbr\u003e\nOsteoarthritis and cartilage repair\u003cbr\u003e\nMetabolic syndrome\u003c\/p\u003e\n\n\u003cp\u003eDue to these properties, AOD9604 has gained attention as a research candidate in weight management and regenerative medicine.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nAOD9604 and Fat Loss\u003cbr\u003e\nAOD9604 was initially developed to replicate the fat-burning effects of hGH without affecting other hormones.\u003c\/p\u003e\n\n\u003cp\u003eClinical Trials: A 12-week Phase 2b clinical trial conducted in Australia tested AOD9604 on 300 obese individuals.\u003cbr\u003e\nResults:\u003c\/p\u003e\n\n\u003cp\u003eParticipants receiving AOD9604 experienced three times more weight loss than the placebo group.\u003cbr\u003e\nConsistent fat reduction was observed throughout the study.\u003c\/p\u003e\n\n\n\u003cp\u003eMetabolic Safety:\u003c\/p\u003e\n\n\u003cp\u003eUnlike full-length hGH, AOD9604 does not elevate IGF-1 or insulin levels.\u003cbr\u003e\nThis makes it a potential safer alternative for individuals at risk of insulin resistance or diabetes.\u003c\/p\u003e\n\n\n\n\u003cp\u003eAOD9604: Mechanism Beyond Beta-3 Adrenergic Receptors\u003cbr\u003e\nEarly research suggested that AOD9604 works by activating beta-3 adrenergic receptors in fat cells, shifting them into fat-burning mode. However, experiments with genetically modified mice lacking these receptors still showed significant fat loss when administered AOD9604.\u003cbr\u003e\nThis suggests that AOD9604 may function through alternative pathways, possibly by:\u003c\/p\u003e\n\n\u003cp\u003eInducing apoptosis (programmed cell death) in white fat cells.\u003cbr\u003e\nRegulating lipid metabolism at the mitochondrial level, increasing energy expenditure.\u003c\/p\u003e\n\n\u003cp\u003eAOD9604 and Joint Health\u003cbr\u003e\nAnimal studies indicate that AOD9604 may have chondroprotective (cartilage-protecting) effects:\u003c\/p\u003e\n\n\u003cp\u003eIn osteoarthritis models (rats \u0026amp; rabbits):\u003c\/p\u003e\n\n\u003cp\u003eDirect intra-articular injections of AOD9604 improved joint function and reduced pain.\u003cbr\u003e\nHistological analysis revealed increased cartilage thickness and better structural integrity.\u003c\/p\u003e\n\n\n\u003cp\u003eSynergistic Effects:\u003c\/p\u003e\n\n\u003cp\u003eWhen combined with other osteoarthritis treatments, AOD9604 enhanced joint repair and functionbeyond standalone therapies.\u003c\/p\u003e\n\n\n\n\u003cp\u003eThese findings suggest potential applications in cartilage regeneration and osteoarthritis management.\u003cbr\u003e\nAOD9604 and Cardiovascular Health\u003cbr\u003e\nWhile fat reduction is inherently linked to heart health, studies suggest AOD9604 may provide direct metabolic benefits independent of weight loss.\u003c\/p\u003e\n\n\u003cp\u003eResearch indicates AOD9604 may enhance heart function in obese individuals.\u003cbr\u003e\nSimilar to metabolic drugs such as pioglitazone and acipimox, AOD9604 improves lipid metabolism, reducing cardiovascular risk factors.\u003c\/p\u003e\n\n\u003cp\u003eAOD9604 Safety Profile\u003cbr\u003e\nAOD9604 has demonstrated a strong safety profile in clinical research:\u003c\/p\u003e\n\n\u003cp\u003eNo significant adverse effects were reported in human trials.\u003cbr\u003e\nDoes not increase blood sugar, IGF-1, or insulin resistance.\u003cbr\u003e\nHighly bioavailable in both oral and subcutaneous forms.\u003c\/p\u003e\n\n\u003cp\u003eImportant Note:\u003cbr\u003e\nAOD9604 is currently for research use only and not approved for human consumption.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₇₈H₁₂₃N₂₃O₂₃S₂\u003cbr\u003e\nMolecular Weight: 1815.12 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe\u003cbr\u003e\nDisulfide Bridge: Cys⁷-Cys¹⁵\u003cbr\u003e\nCAS Registry Number: 386264-39-7\u003cbr\u003e\nPubChem Identifier: 16131447\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eNg F. M. et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm. Res. (2000).\u003cbr\u003e\nStier H. et al. Safety and Tolerability of the Hexadecapeptide AOD9604 in Humans. Journal of Endocrinology and Metabolism (2013).\u003cbr\u003e\nHeffernan M. et al. Effects of Human GH and Its Lipolytic Fragment (AOD9604) on Lipid Metabolism in Obese Mice. Endocrinology (2001).\u003cbr\u003e\nZieba R. Obesity: A review of anti-obesity drugs in clinical development. Postepy Hig. Med. Dosw. (2007).\u003cbr\u003e\nKwon D. R. \u0026amp; Park G. Y. Effect of intra-articular injection of AOD9604 on osteoarthritis in rabbits. Ann. Clin. Lab. Sci. (2015).\u003cbr\u003e\nJensen M. D. Potential role of new therapies in modifying cardiovascular risk in overweight patients with metabolic risk factors. Obesity (Silver Spring) (2006).\u003cbr\u003e\nNews-Medical.net Obesity drug AOD9604 highly successful in trials. (2004).\u003cbr\u003e\nCase Western Reserve University Molecular biology of peptide-derived fat loss agents. J. Mol. Endocrinol. (2015).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561217257,"sku":"PS030","price":50.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/AOD-9604-5MG-scaled.jpg?v=1778509489","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/aod-9604-5mg","provider":"Peptides Verse","version":"1.0","type":"link"}