{"product_id":"cjc-1295-dac-5mg","title":"CJC-1295 DAC 5mg","description":"OVERVIEW\nCJC-1295 is a synthetic analogue of growth hormone-releasing hormone (GHRH) designed to increase plasma levels of growth hormone (GH) and insulin-like growth factor-1 (IGF-1). It is derived from the first 29 amino acids of GHRH, similar to Sermorelin and Modified GRF (1-29), but modified for enhanced stability and efficacy.\nThe DAC (Drug Affinity Complex) version of CJC-1295 includes an additional lysine linker, allowing it to bind to albumin, significantly extending its half-life. This prolonged activity leads to sustained GH release, reducing the need for frequent dosing compared to non-DAC versions.\nKey Benefits of CJC-1295 DAC:\n\nIncreases GH and IGF-1 levels\nEnhances protein synthesis and muscle recovery\nBoosts fat metabolism and supports weight management\nImproves sleep quality and cognitive function\nPreserves natural GH pulsatility, reducing side effects\n\nRESEARCH\nCJC-1295 and Growth Hormone Release\nCJC-1295 binds to GHRH receptors, triggering GH secretion while maintaining the body’s natural pulsatile rhythm. Research findings indicate that:\n\nA single dose of CJC-1295 can increase GH levels by 2-10 times.\nPeak GH secretion occurs around 2 hours post-administration and remains elevated for 6-8 days.\nUnlike exogenous GH injections, which can suppress natural GH production, CJC-1295 stimulates endogenous GH release, minimizing suppression risks.\n\nComparison: CJC-1295 vs. CJC-1295 DAC\n\n\n\nFeature\nCJC-1295 (No DAC)\nCJC-1295 DAC\n\n\nHalf-Life\n~30 minutes\n~8 days\n\n\nDosing Frequency\nMultiple injections daily\nWeekly\n\n\nMechanism\nShort-acting GHRH analogue\nBinds to albumin for sustained GH release\n\n\n\nThe DAC modification allows CJC-1295 to stay in circulation longer, preventing rapid degradation, and promoting longer-lasting GH stimulation.\nEffects on Muscle Growth\nAnimal studies suggest that CJC-1295 enhances lean body mass through:\n\nIncreased protein synthesis, supporting muscle hypertrophy and faster recovery.\nImproved nitrogen retention, aiding in muscle maintenance.\nEnhanced mitochondrial function, potentially boosting endurance and energy production.\n\nCJC-1295 and Fat Metabolism\nCJC-1295 has been linked to fat reduction and improved metabolic function by:\n\nEnhancing GH-induced fatty acid oxidation, leading to more efficient fat breakdown.\nReducing fat accumulation, particularly visceral and subcutaneous fat.\nImproving insulin sensitivity, which helps regulate glucose levels and metabolic efficiency.\n\nClinical studies indicate significant fat loss in subjects using CJC-1295 over 12-24 weeks.\nCJC-1295 and Sleep Quality\nResearch suggests that CJC-1295 may play a role in enhancing sleep cycles, particularly:\n\nIncreasing deep (slow-wave) sleep, crucial for muscle repair, memory consolidation, and recovery.\nModulating cortisol and stress hormones, leading to better relaxation and stress resilience.\n\nThese sleep-related benefits contribute to overall well-being, cognitive function, and physical recovery.\nCJC-1295 and Anti-Aging Potential\nDue to its ability to boost GH and IGF-1 levels, CJC-1295 has been explored for its potential in longevity and regenerative medicine. Benefits may include:\n\nImproved bone density, reducing age-related bone loss.\nEnhanced skin elasticity and collagen production, contributing to youthful skin.\nCognitive protection, potentially aiding in neuroprotection and memory retention.\n\nSTRUCTURE\n\nMolecular Formula: C₁₅₂H₂₅₂N₄₄O₄₂\nMolecular Weight: 3647.954 g\/mol\nAmino Acid Sequence: Tyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-Lys-DAC\nCAS Registry Number: 446262-90-4\nPubChem Identifier: 91976842\n\nCITATIONS\n\nIonescu, M., \u0026amp; Frohman, L. A. Pulsatile secretion of growth hormone persists during continuous stimulation by CJC-1295. J. Clin. Endocrinol. Metab. (2006).\nAlba, M. et al. Once-daily administration of CJC-1295, a long-acting GHRH analog, normalizes growth in knockout mice. Am. J. Physiol. Endocrinol. Metab. (2006).\nVolpe, A. et al. Clinical use of growth hormone-releasing factor for induction of superovulation. Hum. Reprod. (1991).\nJetté, L. et al. hGRF1-29-Albumin Bioconjugates Activate the GRF Receptor on the Anterior Pituitary in Rats.Research Gate (2005).","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561315561,"sku":"PS026","price":55.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/CJC-1295-DAC-5MG-scaled.jpg?v=1778509491","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/cjc-1295-dac-5mg","provider":"Peptides Verse","version":"1.0","type":"link"}