{"product_id":"ipamorelin-5mg","title":"Ipamorelin 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nIpamorelin is a highly selective growth hormone secretagogue (GHS) that binds specifically to the ghrelin\/growth hormone secretagogue receptor (GHS-R1a). It is one of the most targeted GH secretagogues, meaning it does notaffect levels of ACTH, prolactin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), thyroid-stimulating hormone (TSH), or cortisol.\u003cbr\u003e\nDue to its high receptor specificity, Ipamorelin has been widely studied for therapeutic applications and as a model peptide for exploring GH receptor selectivity. It plays a key role in growth, tissue repair, and metabolic regulation.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nIpamorelin and Growth Hormone Release\u003cbr\u003e\nIpamorelin mimics ghrelin, the body’s natural hunger hormone, by binding to GHS-R1a receptors. This interaction leads to:\u003c\/p\u003e\n\n\u003cp\u003eA natural increase in growth hormone (GH) levels.\u003cbr\u003e\nImproved muscle growth, fat metabolism, and tissue repair.\u003cbr\u003e\nPreserved GH pulse frequency without overstimulating the endocrine system.\u003c\/p\u003e\n\n\u003cp\u003eUnlike other GH secretagogues, Ipamorelin stimulates GH release without causing significant increases in cortisol or prolactin levels, making it a safer option for long-term use.\u003cbr\u003e\nIpamorelin and Corticosteroid Side Effects\u003cbr\u003e\nGlucocorticoids (steroids) are often used to treat inflammatory diseases and cancer, but long-term use can lead to:\u003c\/p\u003e\n\n\u003cp\u003eMuscle wasting\u003cbr\u003e\nLoss of bone density\u003cbr\u003e\nIncreased visceral fat accumulation\u003c\/p\u003e\n\n\u003cp\u003eStudies suggest that Ipamorelin may counteract these side effects by:\u003c\/p\u003e\n\n\u003cp\u003eReducing muscle breakdown.\u003cbr\u003e\nPreventing bone loss associated with prolonged steroid use.\u003cbr\u003e\nPreserving nitrogen balance, which is crucial for muscle maintenance and recovery.\u003c\/p\u003e\n\n\u003cp\u003eIpamorelin and Bone Health\u003cbr\u003e\nChronic steroid use is linked to osteoporosis and increased fracture risk. Research in animal models has demonstrated that Ipamorelin can:\u003c\/p\u003e\n\n\u003cp\u003ePrevent bone density loss.\u003cbr\u003e\nStimulate osteoblast activity, promoting new bone formation.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest Ipamorelin may have therapeutic applications in conditions like osteoporosis and age-related bone deterioration.\u003cbr\u003e\nIpamorelin and Muscle Growth\u003cbr\u003e\nIpamorelin’s ability to enhance protein synthesis makes it beneficial for:\u003c\/p\u003e\n\n\u003cp\u003eIncreasing muscle mass and improving recovery.\u003cbr\u003e\nPreventing muscle wasting conditions, such as cachexia and sarcopenia.\u003cbr\u003e\nSupporting post-surgical healing and injury rehabilitation.\u003c\/p\u003e\n\n\u003cp\u003eBy promoting muscle hypertrophy and repair, Ipamorelin has gained interest in sports medicine and anti-aging research.\u003cbr\u003e\nIpamorelin and Diabetes Research\u003cbr\u003e\nStudies suggest that Ipamorelin can stimulate insulin release by activating calcium channels in pancreatic islet cells. This mechanism may:\u003c\/p\u003e\n\n\u003cp\u003eImprove insulin sensitivity.\u003cbr\u003e\nAid in blood sugar regulation.\u003c\/p\u003e\n\n\u003cp\u003eThese findings indicate that Ipamorelin may be explored as a potential treatment for diabetes.\u003cbr\u003e\nIpamorelin and Post-Operative Ileus (POI)\u003cbr\u003e\nPost-operative ileus (POI) occurs when the digestive tract temporarily stops functioning after surgery, delaying recovery.\u003cbr\u003e\nClinical trials have shown that Ipamorelin:\u003c\/p\u003e\n\n\u003cp\u003eReduces POI symptoms.\u003cbr\u003e\nShortens hospital stays by an average of 12 hours.\u003c\/p\u003e\n\n\u003cp\u003eAlthough initial results were promising, further research on Ipamorelin for POI treatment was discontinued due to insufficient efficacy in large-scale trials.\u003cbr\u003e\nIpamorelin and PET Imaging\u003cbr\u003e\nAs a potent ghrelin receptor agonist, Ipamorelin has potential applications in diagnostic imaging:\u003c\/p\u003e\n\n\u003cp\u003eCould be used in PET scans to detect ghrelin receptor-overexpressing tumors.\u003cbr\u003e\nMay aid in diagnosing conditions related to GH deficiency or metabolic disorders.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₃₈H₄₉N₉O₅\u003cbr\u003e\nMolecular Weight: 711.868 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Aib-His-D-2Nal-D-Phe-Lys\u003cbr\u003e\nCAS Registry Number: 170851-70-4\u003cbr\u003e\nPubChem Identifier: 9831659\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eRaun, K. et al. Ipamorelin, the first selective growth hormone secretagogue. Eur. J. Endocrinol. (1998).\u003cbr\u003e\nAndersen, N. B. et al. The growth hormone secretagogue ipamorelin counteracts glucocorticoid-induced bone loss. Growth Horm. IGF Res. (2001).\u003cbr\u003e\nSvensson, J. et al. Ipamorelin increases bone mineral content in female rats. J. Endocrinol. (2000).\u003cbr\u003e\nAagaard, N. K. et al. GH secretagogues reduce nitrogen loss in steroid-treated rats. Growth Horm. IGF Res. (2009).\u003cbr\u003e\nAdeghate, E. \u0026amp; Ponery, A. S. Ipamorelin stimulates insulin release in diabetic rats. Neuro Endocrinol. Lett. (2004).\u003cbr\u003e\nBeck, D. E. et al. Ipamorelin for management of post-operative ileus in bowel resection patients. Int. J. Colorectal Dis. (2014).\u003cbr\u003e\nGreenwood-Van Meerveld, B. et al. Ipamorelin improves gastric dysmotility in POI models. J. Exp. Pharmacol. (2012).\u003cbr\u003e\nFowkes, M. M. et al. Peptidomimetic GH secretagogue derivatives for PET imaging. Eur. J. Med. Chem. (2018).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561282793,"sku":"PS027","price":50.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Ipamorelin-5mg-scaled.jpg?v=1778509490","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/ipamorelin-5mg","provider":"Peptides Verse","version":"1.0","type":"link"}