{"product_id":"kisspeptin-10-5mg","title":"Kisspeptin-10 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nKisspeptin-10 (KP-10) is a naturally occurring peptide that plays a critical role in reproductive hormone regulation. It serves as the primary trigger for the release of gonadotropin-releasing hormone (GnRH), which regulates key reproductive hormones such as testosterone, estrogen, and luteinizing hormone (LH).\u003cbr\u003e\nBeyond its well-established role in reproductive function, emerging research suggests Kisspeptin-10 may also contribute to:\u003c\/p\u003e\n\n\u003cp\u003eEnhancing fertility and reproductive health\u003cbr\u003e\nIncreasing testosterone levels in males\u003cbr\u003e\nRegulating mood, motivation, and behavior\u003cbr\u003e\nModulating energy balance and metabolism\u003cbr\u003e\nSuppressing tumor growth and cancer metastasis\u003c\/p\u003e\n\n\u003cp\u003eThese potential benefits make KP-10 a promising candidate for therapeutic applications in reproductive medicine, endocrinology, neurology, and oncology.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nReproductive Hormone Regulation\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin-10 initiates the release of GnRH, which stimulates LH and FSH secretion from the pituitary gland.\u003cbr\u003e\nThis regulatory function makes it essential for puberty onset, fertility, and overall reproductive function.\u003cbr\u003e\nPotential application: Treatment of delayed puberty, hypogonadism, and infertility.\u003c\/p\u003e\n\n\u003cp\u003eTestosterone Enhancement\u003c\/p\u003e\n\n\u003cp\u003eClinical studies show that KP-10 significantly increases testosterone levels in men within 90 minutes of administration.\u003cbr\u003e\nThis occurs by modulating LH pulse frequency, which fine-tunes the natural release of sex hormones.\u003cbr\u003e\nPotential application: Hormonal therapy and fertility enhancement in males.\u003c\/p\u003e\n\n\u003cp\u003eMood, Motivation, and Libido\u003c\/p\u003e\n\n\u003cp\u003eResearch links Kisspeptin to brain regions involved in reward-seeking behavior, motivation, and emotional regulation.\u003cbr\u003e\nA clinical study on 29 men found that KP-10 administration enhanced limbic brain activity, suggesting benefits in treating low libido and mood disorders.\u003cbr\u003e\nPotential application: Treatment for hypoactive sexual desire disorder (HSDD) and mood-related conditions.\u003c\/p\u003e\n\n\u003cp\u003eEnergy Balance and Metabolism\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin neurons are highly sensitive to nutritional status, influencing GnRH release based on energy availability.\u003cbr\u003e\nStudies in genetically modified mice lacking Kiss1 receptors showed weight gain and reduced energy expenditure, indicating a role in obesity regulation.\u003cbr\u003e\nPotential application: Obesity management and metabolic health support.\u003c\/p\u003e\n\n\u003cp\u003eAnti-Cancer Research\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin-10 has been linked to tumor suppression by reducing metastatic spread in various cancers.\u003cbr\u003e\nA groundbreaking study found that KP-10 suppressed melanoma metastasis by 95%.\u003cbr\u003e\nAltered kisspeptin levels have also been observed in breast, prostate, bladder, ovarian, and thyroid cancers, suggesting a role in tumor migration suppression.\u003cbr\u003e\nPotential application: Development of kisspeptin-based cancer therapies.\u003c\/p\u003e\n\n\u003cp\u003eMemory and Cognitive Function\u003c\/p\u003e\n\n\u003cp\u003eResearch suggests Kisspeptin analogs may enhance memory retention and cognitive flexibility.\u003cbr\u003e\nStudies in mice indicate that KP-10 counteracts learning impairments associated with alcohol exposure.\u003cbr\u003e\nPotential application: Neurological research and cognitive function support.\u003c\/p\u003e\n\n\u003cp\u003eKidney and Cardiovascular Health\u003c\/p\u003e\n\n\u003cp\u003eKisspeptin receptors have been identified in the kidneys, where they support glomerular development and function.\u003cbr\u003e\nKP-10 has been linked to blood vessel function and cardiac output regulation, making it a potential therapeutic target for cardiovascular diseases.\u003cbr\u003e\nPotential application: Cardiovascular health and kidney disease treatment.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eAmino Acid Sequence: YNWNSFGLRF\u003cbr\u003e\nMolecular Formula: C₆₃H₈₃N₁₇O₁₄\u003cbr\u003e\nMolecular Weight: 1302.4 g\/mol\u003cbr\u003e\nCAS Registry Number: 388138-21-4\u003cbr\u003e\nSynonyms: KISS-1, Protein KISS-1, Metastin, KP-10 Peptide\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eW. S. Dhillo et al. Kisspeptin-54 stimulates the hypothalamic-pituitary-gonadal axis in human males. J. Clin. Endocrinol. Metab. (2005).\u003cbr\u003e\nJ. T. George et al. Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men. J. Clin. Endocrinol. Metab. (2011).\u003cbr\u003e\nC. J. L. Harter, G. S. Kavanagh, and J. T. Smith. The role of kisspeptin neurons in reproduction and metabolism. J. Endocrinol. (2018).\u003cbr\u003e\nE. J. Mead et al. Kisspeptins: a multifunctional peptide system with a role in reproduction, cancer, and the cardiovascular system. Br. J. Pharmacol. (2007).\u003cbr\u003e\nT. Ly, S. Harihar, and D. R. Welch. KISS1 in metastatic cancer research and treatment: potential and paradoxes. Cancer Metastasis Rev. (2020).\u003cbr\u003e\nP. Pazarci et al. The effects of daylight exposure on melatonin levels, Kiss1 expression, and melanoma formation in mice. Croat. Med. J. (2020).\u003cbr\u003e\nE. Gibula-Tarlowska and J. H. Kotlinska. Kissorphin improves spatial memory and cognitive flexibility impairment induced by ethanol treatment in the Barnes maze task in rats. Behav. Pharmacol. (2020).\u003cbr\u003e\nA. N. Comninos et al. Kisspeptin modulates sexual and emotional brain processing in humans. J. Clin. Invest. (2017).\u003cbr\u003e\nM. Bhattacharya and A. V. Babwah. Kisspeptin: Beyond the Brain. Endocrinology (2015).\u003cbr\u003e\nAntitumor efficacy of Kisspeptin in human malignant mesothelioma cells. PubMed Central (PMC).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560660201,"sku":"PS052","price":49.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Kisspeptin-10-5mg-scaled.jpg?v=1778509473","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/kisspeptin-10-5mg","provider":"Peptides Verse","version":"1.0","type":"link"}