{"product_id":"melanotan-2-10mg","title":"Melanotan 2 10mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nMelanotan-2 (MT-2) is a synthetic analogue of alpha-melanocyte-stimulating hormone (α-MSH), originally developed in the 1980s. It is known for its ability to:\u003c\/p\u003e\n\n\u003cp\u003eEnhance sexual arousal\u003cbr\u003e\nRegulate compulsive and addictive behaviors\u003cbr\u003e\nSuppress appetite and reduce fat storage\u003cbr\u003e\nIncrease melanin production, leading to a tanning effect\u003cbr\u003e\nPossibly influence neurodevelopmental conditions like autism when used in early stages\u003c\/p\u003e\n\n\u003cp\u003eMT-2 exerts its effects by binding to melanocortin receptors, primarily MC-1R and MC-4R, which are involved in pigmentation, metabolic regulation, and sexual function.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nMelanotan-2 and Melanocortin Receptor Activation\u003cbr\u003e\nMT-2 interacts with five known melanocortin receptors (MCRs), each serving distinct functions:\u003c\/p\u003e\n\n\u003cp\u003eMC-1R: Found in melanocytes, responsible for skin and hair pigmentation.\u003cbr\u003e\nMC-2R: Located in the adrenal glands, involved in cortisol and adrenal hormone secretion.\u003cbr\u003e\nMC-3R: Regulates appetite and energy metabolism.\u003cbr\u003e\nMC-4R: Plays a role in food intake, sexual behavior, and metabolic balance.\u003cbr\u003e\nMC-5R: Expressed in sweat glands and pancreatic islet cells, contributing to sebum production and insulin function.\u003c\/p\u003e\n\n\u003cp\u003eMT-2 and Autism Research\u003cbr\u003e\nRecent studies suggest that Melanotan-2 may influence autism-related behaviors in animal models. Research has shown that MT-2:\u003c\/p\u003e\n\n\u003cp\u003eEnhances oxytocin receptor expression in key brain regions.\u003cbr\u003e\nImproves social interaction and communication in autism spectrum disorder (ASD) models.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest that MT-2 may modulate oxytocin pathways, which play a role in social bonding and emotional regulation.\u003cbr\u003e\nMT-2 and Appetite Suppression\u003cbr\u003e\nMelanotan-2 has been found to reduce hunger and fat storage by activating MC-4R receptors in the hypothalamus. Research indicates that:\u003c\/p\u003e\n\n\u003cp\u003eMice treated with MT-2 significantly decreased food intake and changed their dietary preferences.\u003cbr\u003e\nMT-2 reduced cravings for high-fat foods, which are typically preferred in normal conditions.\u003cbr\u003e\nIt mimics leptin (the satiety hormone) but appears to be more effective in controlling hunger.\u003c\/p\u003e\n\n\u003cp\u003eThese findings highlight the potential of Melanotan-2 as a therapeutic tool for obesity management.\u003cbr\u003e\nMT-2 and Diabetes Management\u003cbr\u003e\nMT-2 has been studied for its potential role in blood sugar regulation, with findings suggesting that it can:\u003c\/p\u003e\n\n\u003cp\u003eLower blood glucose levels.\u003cbr\u003e\nReduce glucagon secretion, which helps regulate blood sugar.\u003cbr\u003e\nInhibit ketone body production, potentially preventing complications associated with diabetes.\u003c\/p\u003e\n\n\u003cp\u003eUnlike leptin, MT-2 can cross the blood-brain barrier in significant amounts, making it a more promising candidate for metabolic regulation.\u003cbr\u003e\nMT-2 and Addiction\/Impulse Control\u003cbr\u003e\nResearch suggests that Melanotan-2 may help regulate impulse control and reduce addictive behaviors, particularly in alcohol dependency. Studies have shown:\u003c\/p\u003e\n\n\u003cp\u003eRats treated with MT-2 significantly reduced alcohol consumption and instead chose water.\u003cbr\u003e\nMT-2 enhances the effects of naltrexone, a common anti-addiction medication, reducing binge drinking behaviors in mice.\u003c\/p\u003e\n\n\u003cp\u003eThese findings indicate that MT-2 may hold potential for treating alcoholism and other impulse-control disorders.\u003cbr\u003e\nMT-2 and Erectile Dysfunction\u003cbr\u003e\nOne of the earliest research areas for Melanotan-2 was its role in treating erectile dysfunction (ED). Key findings include:\u003c\/p\u003e\n\n\u003cp\u003eMT-2 proved effective in men who did not respond to sildenafil (Viagra).\u003cbr\u003e\nUp to 80% of men who failed Viagra treatment showed positive results with MT-2.\u003cbr\u003e\nIt works through central nervous system pathways, making it beneficial for both male and female sexual dysfunction.\u003c\/p\u003e\n\n\u003cp\u003eThese studies suggest that Melanotan-2 may be a viable alternative for individuals with treatment-resistant ED.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₅₀H₆₉N₁₅O₉\u003cbr\u003e\nMolecular Weight: 1024.198 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)\u003cbr\u003e\nCAS Registry Number: 121062-08-6\u003cbr\u003e\nPubChem Identifier: 92432\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eMinakova E. et al. Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism. PLoS ONE (2019).\u003cbr\u003e\nvan der Klaauw A. et al. Role of melanocortin signaling in the preference for dietary macronutrients in human beings. Lancet Lond. Engl. (2015).\u003cbr\u003e\nShimizu H., Inoue K., Mori M. The leptin-dependent and -independent melanocortin signaling system: regulation of feeding and energy expenditure. J. Endocrinol. (2007).\u003cbr\u003e\nBjørbaek C., Hollenberg A. N. Leptin and melanocortin signaling in the hypothalamus. Vitam. Horm. (2002).\u003cbr\u003e\nGuo F., Bakal K., Minokoshi Y., Hollenberg A. N. Leptin Signaling Targets the Thyrotropin-Releasing Hormone Gene Promoter in Vivo. Endocrinology (2004).\u003cbr\u003e\nLee Y. H., Wang M. Y., Yu X. X., Unger R. H. Glucagon is the key factor in the development of diabetes.Diabetologia (2016).\u003cbr\u003e\nToda C. et al. Distinct effects of leptin and a melanocortin receptor agonist injected into medial hypothalamic nuclei on glucose uptake in peripheral tissues. Diabetes (2009).\u003cbr\u003e\nYork D. A., Boghossian S., Park-York M. Melanocortin activity in the amygdala influences alcohol intake.Pharmacol. Biochem. Behav. (2011).\u003cbr\u003e\nNavarro M., Carvajal F., Lerma-Cabrera J. M., Cubero I., Picker M. J., Thiele T. E. Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL\/6J Mice. Alcohol. Clin. Exp. Res. (2015).\u003cbr\u003e\nWessells H. et al. MT-II Induces Penile Erection via Brain and Spinal Mechanisms. Annals of the New York Academy of Sciences (2003).\u003cbr\u003e\nWessells H. Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: Double-blind placebo-controlled crossover study. Nature (1998).\u003cbr\u003e\nLau J. K. Y. et al. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Scientific Reports (2021).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561381097,"sku":"PS024","price":72.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Melatonin-2-10mg-scaled.jpg?v=1778509493","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/melanotan-2-10mg","provider":"Peptides Verse","version":"1.0","type":"link"}