{"product_id":"mots-c-10mg","title":"MOTS-C 10mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nMOTS-c is a mitochondria-derived peptide (MDP) composed of 16 amino acids that plays a critical role in metabolic regulation, mitochondrial function, and cellular stress response. Unlike traditional peptides, MOTS-c is synthesized within mitochondria and translocates to the nucleus, where it regulates gene expression related to energy metabolism and longevity.\u003cbr\u003e\nKey Benefits of MOTS-c Research:\u003cbr\u003e\n✔️ Enhances muscle metabolism and exercise capacity\u003cbr\u003e\n✔️ Promotes fat oxidation and prevents obesity\u003cbr\u003e\n✔️ Improves insulin sensitivity and helps prevent Type 2 diabetes\u003cbr\u003e\n✔️ Protects against age-related diseases and enhances longevity\u003cbr\u003e\n✔️ Supports cardiovascular and bone health\u003cbr\u003e\nMOTS-c is being actively studied in metabolic disorders, aging research, and mitochondrial medicine.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\n1. Muscle Metabolism \u0026amp; Exercise Performance\u003c\/p\u003e\n\n\u003cp\u003eMOTS-c enhances AMPK activation, improving glucose uptake in muscle tissue.\u003cbr\u003e\nStudies in mice show that MOTS-c increases endurance and muscle recovery post-exercise.\u003cbr\u003e\nPotential application: Exercise enhancement, muscle recovery, and metabolic health support.\u003c\/p\u003e\n\n\u003cp\u003e2. Fat Metabolism \u0026amp; Obesity Prevention\u003c\/p\u003e\n\n\u003cp\u003eMOTS-c stimulates brown fat activation, promoting fat oxidation over storage.\u003cbr\u003e\nResearch indicates that MOTS-c supplementation prevents adipose tissue dysfunction and white fat accumulation.\u003cbr\u003e\nPotential application: Obesity treatment, fat metabolism regulation, and ketogenic diet support.\u003c\/p\u003e\n\n\u003cp\u003e3. Insulin Sensitivity \u0026amp; Diabetes Prevention\u003c\/p\u003e\n\n\u003cp\u003eLow MOTS-c levels are correlated with insulin resistance, particularly in obese individuals.\u003cbr\u003e\nMOTS-c supplementation enhances glucose metabolism and insulin sensitivity, making it a potential therapy for Type 2 diabetes.\u003cbr\u003e\nPotential application: Diabetes prevention, metabolic syndrome treatment, and insulin resistance improvement.\u003c\/p\u003e\n\n\u003cp\u003e4. Longevity \u0026amp; Aging Research\u003c\/p\u003e\n\n\u003cp\u003eMOTS-c levels decline with age, and genetic studies link its variants to exceptional longevity (especially in Japanese centenarians).\u003cbr\u003e\nMOTS-c supplementation has been associated with improved mitochondrial function and protection against age-related diseases.\u003cbr\u003e\nPotential application: Longevity enhancement, anti-aging therapy, and mitochondrial function support.\u003c\/p\u003e\n\n\u003cp\u003e5. Cardiovascular Health\u003c\/p\u003e\n\n\u003cp\u003eMOTS-c improves endothelial function, reducing inflammation and oxidative stress in blood vessels.\u003cbr\u003e\nClinical research shows lower MOTS-c levels correlate with a higher risk of coronary artery disease.\u003cbr\u003e\nPotential application: Cardiovascular disease prevention, blood vessel protection, and heart health improvement.\u003c\/p\u003e\n\n\u003cp\u003e6. Bone Health \u0026amp; Osteoporosis Prevention\u003c\/p\u003e\n\n\u003cp\u003eMOTS-c activates the TGF-β\/SMAD signaling pathway, stimulating osteoblast activity and Type I collagen production.\u003cbr\u003e\nStudies suggest that MOTS-c enhances bone density and reduces fracture risk.\u003cbr\u003e\nPotential application: Osteoporosis prevention and bone regeneration therapy.\u003c\/p\u003e\n\n\u003cp\u003e7. Metabolic Stress \u0026amp; Mitochondrial Function\u003c\/p\u003e\n\n\u003cp\u003eMOTS-c acts as a mitochondrial stress response peptide, regulating nuclear gene expression to counteract metabolic dysfunction.\u003cbr\u003e\nIt influences glucose metabolism and antioxidant defense, offering protection against metabolic diseases.\u003cbr\u003e\nPotential application: Mitochondrial medicine, metabolic disease treatment, and cellular stress response regulation.\u003c\/p\u003e\n\n\u003cp\u003eSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eAmino Acid Sequence: Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg\u003cbr\u003e\nMolecular Formula: C₁₀₁H₁₅₂N₂₈O₂₂S₂\u003cbr\u003e\nMolecular Weight: 2174.64 g\/mol\u003cbr\u003e\nCAS Registry Number: 1627580-64-6\u003cbr\u003e\nSynonyms: Mitochondrial Open Reading Frame of the 12S rRNA-c (MT-RNR1), MOTS-c Peptide\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eC. Lee, K. H. Kim, \u0026amp; P. Cohen. MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic. Biol. Med. (2016).\u003cbr\u003e\nH. Lu et al. MOTS-c peptide regulates adipose homeostasis to prevent ovariectomy-induced metabolic dysfunction. J. Mol. Med. Berl. Ger. (2019).\u003cbr\u003e\nK. H. Kim et al. MOTS-c translocates to the nucleus to regulate nuclear gene expression in response to metabolic stress. Cell Metab. (2018).\u003cbr\u003e\nS.-J. Kim et al. MOTS-c enhances insulin sensitivity and regulates plasma metabolites. Physiol. Rep. (2019).\u003cbr\u003e\nL. R. Cataldo et al. Plasma MOTS-c levels are associated with insulin sensitivity in lean but not obese individuals. J. Investig. Med. (2018).\u003cbr\u003e\nN. Che et al. MOTS-c improves osteoporosis by promoting Type I collagen synthesis in osteoblasts via TGF-β\/SMAD signaling pathway. Eur. Rev. Med. Pharmacol. Sci. (2019).\u003cbr\u003e\nN. Fuku et al. MOTS-c as a key player in exceptional longevity. Aging Cell (2015).\u003cbr\u003e\nQ. Qin et al. Downregulation of circulating MOTS-c levels in patients with coronary endothelial dysfunction. Int. J. Cardiol. (2018).\u003cbr\u003e\nY. Yang et al. MOTS-c’s role in cardiovascular disease: Recent updates. Biomed. Pharmacother. (2019).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560529129,"sku":"PS056","price":75.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/mots-c-10mg-scaled.jpg?v=1778509469","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/mots-c-10mg","provider":"Peptides Verse","version":"1.0","type":"link"}