{"product_id":"pt-141-10mg","title":"PT-141 10mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nPT-141, also known as Bremelanotide, is a synthetic derivative of alpha-melanocyte-stimulating hormone (α-MSH). Initially developed to treat sexual dysfunction in both men and women, it has also been explored for its immune-modulating properties and potential applications in hemorrhagic shock treatment.\u003cbr\u003e\nPT-141 functions as a melanocortin receptor (MC) agonist, primarily targeting MC-4R and MC-1R, which play roles in sexual arousal, immune function, and vascular regulation. Research suggests that PT-141 can:\u003c\/p\u003e\n\n\u003cp\u003eEnhance libido and sexual arousal.\u003cbr\u003e\nImprove erectile function in men and increase sexual desire in women.\u003cbr\u003e\nStimulate immune system activity.\u003cbr\u003e\nReduce inflammation and ischemic damage.\u003c\/p\u003e\n\n\u003cp\u003eUnlike traditional PDE5 inhibitors (e.g., Viagra, Cialis), which work by increasing blood flow, PT-141 acts directly on the central nervous system, making it a potential alternative for individuals with psychogenic sexual dysfunction.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nPT-141 and Sexual Arousal\u003cbr\u003e\nPT-141’s impact on sexual function is linked to its activation of the MC-4R receptor, found in the central nervous system and associated with sexual behavior and arousal.\u003c\/p\u003e\n\n\u003cp\u003eAnimal studies showed that MC-4R activation increased mating behavior in both male and female subjects.\u003cbr\u003e\nClinical trials in men with erectile dysfunction (ED)—including those unresponsive to sildenafil (Viagra)—revealed that one-third of participants achieved sufficient erections with PT-141.\u003cbr\u003e\nPre-menopausal women with hypoactive sexual desire disorder (HSDD) experienced:\u003c\/p\u003e\n\n\u003cp\u003eIncreased frequency of satisfying sexual events.\u003cbr\u003e\nReduced distress related to low sexual desire.\u003c\/p\u003e\n\n\n\n\u003cp\u003eBecause PT-141 acts via the brain and not the vascular system, it may be particularly effective for non-vascular causes of sexual dysfunction.\u003cbr\u003e\nPT-141 and Hemorrhagic Shock\u003cbr\u003e\nIn 2009, PT-141 was investigated for acute hemorrhage treatment, with research suggesting potential emergency medicine applications.\u003c\/p\u003e\n\n\u003cp\u003eThe MC-1R receptor plays a key role in vascular response and blood flow regulation.\u003cbr\u003e\nStudies indicated that PT-141 enhanced vascular integrity and reduced ischemic damage in hemorrhagic shock models.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest PT-141 or its derivatives could be explored for trauma and critical care medicine.\u003cbr\u003e\nPT-141 and Immune System Modulation\u003cbr\u003e\nPT-141 also targets the MC-1R receptor, which is involved in immune regulation.\u003c\/p\u003e\n\n\u003cp\u003eAnimal studies suggest PT-141 may exhibit:\u003c\/p\u003e\n\n\u003cp\u003eAnti-inflammatory properties.\u003cbr\u003e\nAntimicrobial effects, potentially aiding in infection control.\u003c\/p\u003e\n\n\n\u003cp\u003eMC-1R activation has been linked to immune system support in autoimmune conditions and inflammatory diseases.\u003c\/p\u003e\n\n\u003cp\u003eThis research highlights PT-141’s potential beyond sexual health, particularly in immune and inflammatory disorders.\u003cbr\u003e\nPT-141 and Cancer Research\u003cbr\u003e\nRecent studies suggest that PT-141 may influence DNA repair mechanisms:\u003c\/p\u003e\n\n\u003cp\u003eThe MC-1R receptor is involved in DNA damage repair pathways.\u003cbr\u003e\nIndividuals with MC-1R mutations have a higher risk of melanoma and skin cancer.\u003c\/p\u003e\n\n\u003cp\u003eOngoing research aims to determine whether PT-141 could help prevent certain cancers or support DNA repair in high-risk individuals.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₅₀H₆₈N₁₄O₁₀\u003cbr\u003e\nMolecular Weight: 1025.182 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Ac-Nle-Asp(1)-His-D-Phe-Arg-Trp-Lys(1)\u003cbr\u003e\nCAS Registry Number: 189691-06-3\u003cbr\u003e\nPubChem Identifier: 9941379\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eRosen, R. C. et al. Evaluation of the safety, pharmacokinetics, and pharmacodynamic effects of subcutaneously administered PT-141, a melanocortin receptor agonist, in healthy male subjects and in patients with an inadequate response to Viagra. International Journal of Impotence Research (2004).\u003cbr\u003e\nWessells, H. et al. PT-141 induces penile erection via brain and spinal melanocortin receptors. Neuroscience (2003).\u003cbr\u003e\nRössler, A.-S. et al. The melanocortin agonist, Melanotan II, enhances proceptive sexual behaviors in female rats. Pharmacology, Biochemistry, and Behavior (2006).\u003cbr\u003e\nSafarinejad, M. R. \u0026amp; Hosseini, S. Y. Salvage of sildenafil failures with bremelanotide: a randomized, double-blind, placebo-controlled study. Journal of Urology (2008).\u003cbr\u003e\nClayton, A. H. et al. Bremelanotide for female sexual dysfunctions in premenopausal women: a randomized, placebo-controlled dose-finding trial. Women’s Health (London, England) (2016).\u003cbr\u003e\nJi, H. et al. The Synthetic Melanocortin (CKPV)2 Exerts Anti-Fungal and Anti-Inflammatory Effects against Candida albicans Vaginitis via Inducing Macrophage M2 Polarization. PLoS ONE (2013).\u003cbr\u003e\nMaresca, V. et al. Skin phototype: a new perspective. Pigment Cell \u0026amp; Melanoma Research (2015).\u003cbr\u003e\nFeller, L. et al. Basal cell carcinoma, squamous cell carcinoma, and melanoma of the head and face. Head \u0026amp; Face Medicine (2016).\u003cbr\u003e\nMcMillan, T. R. et al. Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice. Experimental Physiology (2021).\u003cbr\u003e\nSpana, C. et al. Effect of bremelanotide on body weight of obese women: Data from two phase 1 randomized controlled trials. Diabetes, Obesity, and Metabolism (2022).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561184489,"sku":"PS031","price":55.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/PT-141-10mg-scaled.jpg?v=1778509487","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/pt-141-10mg","provider":"Peptides Verse","version":"1.0","type":"link"}