{"product_id":"selank-5mg","title":"Selank 5mg","description":"\u003cp\u003eOVERVIEW\u003cbr\u003e\nSelank is a synthetic analogue of tuftsin, a naturally occurring immunomodulatory peptide. Originally developed in Russia, it has been extensively studied for its anxiolytic (anti-anxiety), nootropic (cognitive-enhancing), and immune-boosting properties.\u003cbr\u003e\nResearch suggests that Selank may:\u003c\/p\u003e\n\n\u003cp\u003eReduce anxiety without causing sedation or addiction.\u003cbr\u003e\nEnhance memory, learning, and cognitive function.\u003cbr\u003e\nModulate immune system responses, aiding in stress-induced immune dysfunction.\u003cbr\u003e\nRegulate inflammatory cytokines, particularly by suppressing IL-6, a key marker of inflammation.\u003cbr\u003e\nIncrease brain-derived neurotrophic factor (BDNF), supporting neuroplasticity and brain health.\u003c\/p\u003e\n\n\u003cp\u003eDue to its effects on the GABAergic system, Selank is considered a potential alternative to benzodiazepines for treating anxiety-related disorders—without the risk of dependence or withdrawal.\u003cbr\u003e\nRESEARCH\u003cbr\u003e\nSelank and Anxiety Reduction\u003cbr\u003e\nSelank interacts with the GABAergic system, similar to benzodiazepines, but with key distinctions:\u003c\/p\u003e\n\n\u003cp\u003eEnhances GABA receptor sensitivity, promoting a calming effect.\u003cbr\u003e\nDoes not cause dependence, withdrawal symptoms, or cognitive impairment, unlike traditional anxiolytics.\u003cbr\u003e\nIncreases the effectiveness of diazepam (Valium) when combined, suggesting a synergistic mechanism.\u003c\/p\u003e\n\n\u003cp\u003eClinical trials conducted in Russia demonstrated that Selank:\u003c\/p\u003e\n\n\u003cp\u003eSignificantly reduced anxiety and improved mood in patients with generalized anxiety disorder (GAD) and neurasthenia.\u003c\/p\u003e\n\n\u003cp\u003eThese findings highlight Selank’s potential for treating anxiety disorders without the sedation or addiction risksassociated with benzodiazepines.\u003cbr\u003e\nSelank and Cognitive Enhancement\u003cbr\u003e\nSelank has been shown to improve learning, memory retention, and recall through multiple mechanisms:\u003c\/p\u003e\n\n\u003cp\u003eEnhances hippocampal gene expression, supporting neuroplasticity.\u003cbr\u003e\nIncreases neuropeptides that promote long-term memory formation.\u003cbr\u003e\nProtects against cognitive decline after brain injury or stress exposure.\u003c\/p\u003e\n\n\u003cp\u003eAnimal studies indicate that Selank enhances cognitive function even in subjects without anxiety, suggesting direct nootropic effects.\u003cbr\u003e\nSelank and Immune System Modulation\u003cbr\u003e\nSelank is unique among nootropic peptides due to its immune-modulating properties:\u003c\/p\u003e\n\n\u003cp\u003eSuppresses IL-6, a pro-inflammatory cytokine associated with anxiety and depression.\u003cbr\u003e\nRegulates T-helper cell activity, helping to maintain immune balance.\u003cbr\u003e\nDemonstrates antiviral potential, possibly aiding recovery from respiratory infections.\u003c\/p\u003e\n\n\u003cp\u003eThese findings suggest that Selank may benefit individuals with stress-related immune suppression.\u003cbr\u003e\nSelank and Pain Perception\u003cbr\u003e\nSelank influences the endogenous opioid system by:\u003c\/p\u003e\n\n\u003cp\u003ePreventing the breakdown of enkephalins, the body’s natural pain-killing peptides.\u003cbr\u003e\nReducing stress-related hyperalgesia, a condition where anxiety or chronic stress amplifies pain sensitivity.\u003c\/p\u003e\n\n\u003cp\u003eThis mechanism mirrors the effects of opioid receptor modulators and certain antidepressants, making Selank a potential alternative treatment for chronic pain conditions.\u003cbr\u003e\nSTRUCTURE\u003c\/p\u003e\n\n\u003cp\u003eMolecular Formula: C₃₃H₅₇N₁₁O₉\u003cbr\u003e\nMolecular Weight: 751.887 g\/mol\u003cbr\u003e\nAmino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro\u003cbr\u003e\nCAS Registry Number: 129954-34-3\u003cbr\u003e\nPubChem Identifier: 11765600\u003c\/p\u003e\n\n\u003cp\u003eCITATIONS\u003c\/p\u003e\n\n\u003cp\u003eVolkova, A. et al. Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission. Front. Pharmacol. (2016).\u003cbr\u003e\nKasian, A. et al. Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats. Behavioural Neurology (2017).\u003cbr\u003e\nZozulya, A. A. et al. The inhibitory effect of Selank on enkephalin-degrading enzymes as a possible mechanism of its anxiolytic activity. Bull. Exp. Biol. Med. (2001).\u003cbr\u003e\nSokolov, O. Y. et al. Effects of Selank on behavioral reactions and activities of plasma enkephalin-degrading enzymes in mice with different phenotypes of emotional and stress reactions. Bull. Exp. Biol. Med. (2003).\u003cbr\u003e\nUchakina, O. N. et al. Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders. Zh. Nevrol. Psikhiatr. (2008).\u003cbr\u003e\nKolomin, T. et al. Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank. Regul. Pept. (2011).\u003cbr\u003e\nSemenova, T. et al. Effect of Selank on cognitive processes after damage inflicted to the cerebral catecholamine system during early ontogeny. Bull. Exp. Biol. Med. (2014).\u003c\/p\u003e","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989561118953,"sku":"PS033","price":35.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Selank-5mg-scaled.jpg?v=1778509485","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/selank-5mg","provider":"Peptides Verse","version":"1.0","type":"link"}