{"product_id":"semax-10mg","title":"Semax 10mg","description":"OVERVIEW\nSemax is a synthetic derivative of adrenocorticotropic hormone (ACTH), originally developed in Russia for its neuroprotective, cognitive-enhancing, and immune-boosting properties. Research suggests that Semax may:\n\nIncrease brain-derived neurotrophic factor (BDNF), supporting neuroplasticity and learning.\nEnhance immune function and reduce inflammation.\nProtect neurons from ischemic damage, aiding in stroke and traumatic brain injury (TBI) recovery.\nImprove cardiovascular function, potentially enhancing blood circulation.\nAct as an antidepressant and anxiolytic (anti-anxiety agent) by modulating serotonin, dopamine, and BDNF levels.\n\nDue to its ability to support mental performance, reduce stress, and promote neurological recovery, Semax is widely researched in neurology, cognitive enhancement, and immune regulation.\nRESEARCH\nSemax and Stroke Recovery\nSemax has been extensively studied for its neuroprotective effects in stroke and traumatic brain injury (TBI).\n\nIn rat models of stroke, Semax activated 24 genes linked to vascular function, promoting neurogenesis and protecting against ischemic damage.\nClinical trials in stroke patients showed that those receiving Semax experienced faster motor function recovery and improved neurological outcomes.\nBDNF elevation facilitated brain plasticity and functional rehabilitation.\n\nThese findings suggest Semax could be a promising treatment for post-stroke recovery and neurodegenerative conditions.\nSemax and Cognitive Enhancement\nSemax has been studied for its potential as a nootropic (cognitive enhancer):\n\nIncreases BDNF levels in the hippocampus, improving learning and memory formation.\nEnhances prefrontal cortex activity, potentially boosting problem-solving skills and attention span.\nProtects against cognitive decline, possibly preventing age-related memory loss.\n\nThese neuroprotective and cognitive-enhancing effects make Semax a promising compound for cognitive longevity and brain health.\nSemax and the Default Mode Network (DMN)\n\nFunctional MRI studies suggest that Semax activates the Default Mode Network (DMN), a system responsible for:\n\nSocial cognition\nEnvironmental awareness\nResting-state brain activity\n\n\nEnhanced DMN function is linked to better focus, cognitive flexibility, and mental clarity.\nDMN disruptions are associated with neurodegenerative diseases like Alzheimer’s, suggesting Semax may play a neuroprotective role.\n\nSemax and Depression\/Anxiety\nSemax may offer antidepressant and anxiolytic effects by modulating serotonin, dopamine, and BDNF levels.\n\nAnimal studies show that Semax increases BDNF production, reducing depressive symptoms.\nUnlike SSRIs, Semax may work faster by directly increasing neurotrophic support, rather than altering serotonin levels alone.\nPotential as an adjunct therapy with antidepressants for enhanced efficacy.\n\nSemax and Pain Management\nResearch suggests Semax may help regulate pain perception by influencing the opioid system:\n\nPrevents the breakdown of enkephalins, the brain’s natural painkillers.\nMay provide an alternative approach for chronic pain management.\n\nSemax and Immune System Support\n\nSuppresses IL-6, a key inflammatory cytokine involved in stress response and immune dysfunction.\nEnhances T-helper cell activity, leading to better immune system balance.\nPotential antiviral properties, suggesting possible applications in infection recovery.\n\nSTRUCTURE\n\nMolecular Formula: C₃₉H₅₄N₁₀O₁₀S\nMolecular Weight: 854.99 g\/mol\nAmino Acid Sequence: Ac-Met-Glu-His-Phe-Pro-Gly-Pro\nCAS Registry Number: 80714-61-0\nPubChem Identifier: 122178\nSynonyms: Pro-Gly-Pro-ACTH, ACTH(4-10) analog\n\nCITATIONS\n\nLebedeva, I. S. et al. Effects of Semax on the Default Mode Network of the Brain. Bulletin of Experimental Biology and Medicine (2018).\nMars, R. B. et al. On the relationship between the default mode network and the social brain. Front. Hum. Neurosci. (2012).\nMedvedeva, E. V. et al. The peptide Semax affects the expression of genes related to the immune and vascular systems in rat brain focal ischemia. BMC Genomics (2014).\nGusev, E. I. et al. The efficacy of Semax in the treatment of patients at different stages of ischemic stroke.Zhurnal Nevrologii i Psikhiatrii (2018).\nAgapova, T. I. et al. Effect of Semax on BDNF and NGF gene expression in the rat hippocampus and frontal cortex. Molecular Genetics, Microbiology, and Virology (2008).\nScantlebury, M. H. et al. Adrenocorticotropic Hormone Protects Learning and Memory Function in Epileptic Mice. Neuroscience Letters (2017).\nDeltheil, T. et al. Behavioral and serotonergic consequences of increasing hippocampus BDNF protein levels.Neuropharmacology (2008).\nBobyntsev, I. I. et al. Influence of ACTG4-7-PGP (Semax) on the morphofunctional state of hepatocytes in chronic stress. Bulletin of Experimental Biology and Medicine (2017).\nBobyntsev, I. I. et al. The effect of ACTH-4-7-PGP peptide on lipid peroxidation and stress response in rats.Research Gate (2015).","brand":"Biogenesis Peptides","offers":[{"title":"Default Title","offer_id":50989560201449,"sku":"PS034-1","price":80.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0808\/6559\/1529\/files\/Semax-5mg-scaled.jpg?v=1778509460","url":"https:\/\/f1kjgr-r5.myshopify.com\/products\/semax-10mg","provider":"Peptides Verse","version":"1.0","type":"link"}