Molecular Weight: 4731.33 Da | Receptors: GLP-1 · GIP · GCGR | Form: Lyophilized | Purity: 99%+ HPLC
GLP-1R (Retatrutide) is a synthetic triple-receptor agonist — a “GGG tri-agonist” — engineered to simultaneously engage the GLP-1, GIP, and glucagon (GCGR) receptors. Built on a modified GIP peptide backbone with albumin-binding modifications that extend its research half-life, it is one of the most-studied compounds in preclinical metabolic and energy-balance research. Each vial contains 10mg of lyophilized GLP-1R at 99%+ HPLC-verified purity, with a batch-specific Certificate of Analysis available for download. *
Retatrutide
GLP-1R / GIPR / GCGR Tri-Agonist (40mg)
Mechanism of Action• GIPR: Relays fullness / satiety signaling from the gut, supporting food-intake regulation studies.
• GLP-1R: Slows gastric emptying and supports glucose-regulation and metabolic-management research.
• GCGR: Raises glucagon activity, driving fat- and glycogen-breakdown pathways studied for energy expenditure.
| Compound | Retatrutide (GGG tri-agonist) |
| Purity | ≥ 99% HPLC |
| Identity | LC-MS Verified |
| Formula | C₂₂₃H₃₄₃F₃N₄₆O₇₀ |
| MW | 4731.33 g/mol |
| CAS Number | 2381089-83-2 |
| Sequence | YA*QGTFTSDYSIL*LDKK*AQA*AFIEYLLEGGPSSGAPPPS |
| Form | Lyophilized powder |
| Vial Size | 3mL glass vial · 40mg |
| Additives | None |
| Batch COA | Available for download |
- Metabolic disease models (obesity and T2D mechanism)
- Energy-balance & thermogenesis studies
- Incretin signaling & receptor pharmacology
- Appetite-regulation neuroscience
- Glucose-homeostasis and insulin-response research
- Comparative tri-agonist vs single/dual-agonist pharmacology
- Ref: Coskun et al. (2022); Jastreboff et al. (2023); Urva et al. (2023).
Storage: Store lyophilized powder at -20°C for long-term stability. Once reconstituted, store at 4°C. Protect from light and moisture.
Handling: Research use only. Must be handled by licensed, qualified professionals in a laboratory setting using appropriate PPE.
FEATURED INGREDIENTS
All Ingredients
GLP-1 Receptor
Studied for slowing gastric emptying and supporting blood-sugar regulation.
GIP Receptor
Relays satiety signals from the gut to the brain in metabolic research.
Glucagon Receptor
Researched for fat & glycogen breakdown and increased energy expenditure.
PRODUCT BENEFITS
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Triple-Receptor Agonism (GGG) Simultaneously engages the GLP-1, GIP, and glucagon receptors in a single molecule — a unique tool for multi-pathway metabolic signaling research.
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Glucagon-Receptor Energy Metabolism GCGR activation is studied for its role in glycogen and lipid mobilization and increased basal energy expenditure in metabolic models.
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Appetite & Satiety Pathway Research GIP and GLP-1 receptor engagement is researched for central and peripheral appetite-signaling and food-intake regulation in preclinical models.
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Gastric-Emptying & Glucose-Homeostasis Studies Documented in research to slow gastric emptying and modulate glucose regulation — key parameters in incretin pharmacology.
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Extended Research Half-Life Albumin-binding modifications give a prolonged half-life suited to weekly preclinical study protocols.
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99%+ HPLC-Verified Purity Independently verified by third-party laboratories via HPLC and LC-MS; batch-specific COA and SDS available pre-purchase.
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GLP1-R (Retatrutide) activates three metabolic receptors at once — GLP-1, GIP, and glucagon — coordinating a single-molecule response studied for appetite signaling, glucose regulation, and energy expenditure. Its albumin-binding design gives an extended half-life suited to weekly research protocols.*
WHAT TO EXPECT
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
Independently verified by third-party labs
Batch number printed on every vial
Orders before 2 PM EST ship same business day
Plain FedEx/UPS, return label: Shipping Manager
Real human responses within hours
GLP-1 Receptor (GLP-1R)
Slows gastric emptying and supports glucose regulation; widely studied for appetite control and overall metabolic management.
GIP Receptor (GIPR)
Relays fullness signals from the gut to the brain, researched for food-intake regulation and for amplifying the compound's metabolic effect.
Glucagon Receptor (GCGR)
Glucagon-receptor activation is studied for the breakdown of stored fat and glycogen and for raising basal energy expenditure — the third pathway that sets this tri-agonist apart.
ALL INGREDIENTS
- GLP-1 Receptor (GLP-1R) — Slows gastric emptying and supports glucose regulation; widely studied for appetite control and overall metabolic management.
- GIP Receptor (GIPR) — Relays fullness signals from the gut to the brain, researched for food-intake regulation and for amplifying the compound's metabolic effect.
- Glucagon Receptor (GCGR) — Studied for the breakdown of stored fat and glycogen and for increasing basal energy expenditure.
The "GLP1-R" Peptide |
No fillers | No artificial additives | No excipients | 99%+ HPLC verified · batch COA | No repackaged imports | No human-use claims |
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GLP1-R Peptide
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Other Peptide |
The "GLP1-R" Peptide
| Compare to: |  GLP1-R Peptide |
Other Peptide |
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| No fillers | ||
| No artificial additives | ||
| No excipients | ||
| 99%+ HPLC verified · batch COA | ||
| No repackaged imports | ||
| No human-use claims |
FAQs
GHK-Cu (Glycyl-L-Histidyl-L-Lysine Copper Complex) is a naturally occurring copper-binding tripeptide studied extensively in preclinical and in vitro research models. It is primarily researched for its role in tissue repair, collagen synthesis, wound healing, gene expression modulation, hair follicle biology, and antioxidant defense pathways.
Lyophilized means the compound has been freeze-dried — water is removed under vacuum to produce a stable powder. This process significantly extends shelf life and preserves compound integrity during storage and shipping. Lyophilized peptides are the research-grade standard because they maintain purity far longer than liquid formulations.
Each batch of GHK-Cu is independently verified at ≥99% purity using HPLC (High-Performance Liquid Chromatography). Identity is further confirmed by LC-MS (Liquid Chromatography-Mass Spectrometry). A batch-specific Certificate of Analysis (COA) is available for download before purchase.
Store lyophilized GHK-Cu at −20°C upon receipt. Keep protected from light, heat, and moisture. Do not open the vial until needed for your research protocol. Under proper storage conditions, lyophilized GHK-Cu maintains compound integrity for up to 24 months.
No. Peptides Verse does not provide reconstitution, dosing, or administration guidance of any kind. All reconstitution protocols are the sole responsibility of the qualified researcher or institution receiving this compound. This product is strictly for in vitro and laboratory research use only.
Yes. A batch-specific COA is available for every vial of GHK-Cu sold by Peptides Verse. The COA includes HPLC purity data, LC-MS identity confirmation, lot number, and testing lab details. It can be downloaded directly from the product page before or after purchase.
GHK refers to the free tripeptide (Glycyl-L-Histidyl-L-Lysine) without copper. GHK-Cu is the copper-chelated form — where a Cu² ion is bound to the tripeptide. The copper-chelated form is the biologically active version studied in most published research on wound healing, collagen synthesis, and gene expression modulation.
No. GHK-Cu from Peptides Verse is strictly for in vitro research and laboratory experimentation only. It is not intended for human or animal use of any kind. By purchasing, the buyer confirms they are a qualified researcher or institution and accepts full responsibility for safe handling and use.
All orders are shipped via FedEx with temperature-appropriate packaging to protect compound integrity during transit. Packaging is discreet — plain FedEx or UPS with no product branding on the exterior. Orders placed before 2 PM EST ship same business day.
Due to the nature of research chemicals, all sales are final once a vial has been opened or the seal broken. If you receive a damaged or incorrect item, contact support@peptidesverse.com within 48 hours of delivery with your order number and photos.